▪ Abstract Apoptosis is a highly regulated process of cell death that is required for the
development and homeostasis of multicellular organisms. In contrast to necrosis, apoptosis …

Diphtheria is an acute, communicable disease caused by Corynebacterium diphtheriae. The
disease is generally characterized by local growth of the bacterium in the pharynx with …

Cytokine synthesis inhibitory factor (CSIF; interleukin-10), a product of mouse TH2 T cell
clones that inhibits synthesis of cytokines by mouse TH1 T cell clones, exhibits extensive …

Protein toxins such as ricin and Shiga toxin with intracellular targets have to be endocytosed
and translocated to the cytosol to inhibit the protein synthesis and thereby kill the cell. Ricin …

Certain anti-cancer agents are known to induce apoptosis in human tumour cells. However,
these agents are intrinsically cytotoxic against cells of normal tissue origin, including …

To determine the role of BCL-2 in the glucocorticoid-induced apoptosis of lymphocytes, we
analyzed the effect of glucocorticoid on two human pre-B-cell lines which express different …

AbhrcviatiGas: ApUp. adcnyly143', 5'I-uridinc-Y-pho.~ phatc; TINS, 2-p-toluidinylnapthalcnc-
b-sulfonatc; BLM. bilaycr lipid membranes; CD, circular dichroism; DPA. dipicolinic acid; …

The majority of strains of Actinobacillus actinomycetemcomitans isolated from patients with
periodontal diseases secrete a leukotoxin that destroys human myeloid cells within minutes …

The involvement of Ca2+ in the regulation of a large number of physiological processes is
now well established. Along with this knowledge has come the understanding that Ca2+ can …

We have shown that the immunomodulating agent gliotoxin induces DNA fragmentation in
macrophages characteristic of programmed cell death or apoptosis (Waring, P., Eichner, RD …