By integrating enzymatic catalysis with photocatalysis, photoenzymatic catalysis emerges as
a powerful strategy to enhance enzyme catalytic capabilities and provide superior …

The trifluoromethyl (− CF3) group represents a highly prevalent functionality in
pharmaceuticals. Over the past few decades, significant advances have been made in the …

β-Fluoromethyl (CH2F, CHF2, and CF3)-substituted chiral ketones are essential moieties
and are vital building blocks in pharmaceutical and agrochemistry. However, general and …

The introduction of fluoroalkyl groups into pharmaceutical compounds has the potential to
enhance their therapeutic properties. Nevertheless, the synthesis of enantiomerically pure C …

Halogenation significantly enhances the biological activity, stability, and solubility of organic
molecules, and thus is a crucial modification in the biotechnology and pharmaceutical …

Visible light-driven pyridoxal radical biocatalysis has emerged as a new strategy for the
stereoselective synthesis of valuable noncanonical amino acids in a protecting-group-free …

The Class I aldolases are known to construct C–C bonds with high enantioselectivity via
both natural enamine and promiscuous iminium ion intermediates. However, these enzymes …

Dipines are a type of important antihypertensive drug as L-calcium channel blockers, whose
core skeleton is the 1, 4-dihydropyridine structure. Since the dihydropyridine ring is a key …

Vicinal diamines are key motifs widely-found in many pharmaceuticals and biologically
active molecules. An appealing approach for synthesizing these molecules is the amination …

An efficient photocatalytic system based on an artificially engineered photoenzyme, BSA-
TXO, has been developed for the oxidative cleavage of various alkenes into ketones. This …