Diosgenin: an updated pharmacological review and therapeutic perspectives

P Semwal, S Painuli, T Abu-Izneid… - Oxidative medicine …, 2022 - Wiley Online Library
Plants including Rhizoma polgonati, Smilax china, and Trigonella foenum-graecum contain
a lot of diosgenin, a steroidal sapogenin. This bioactive phytochemical has shown high …

Advances in the biosynthesis and molecular evolution of steroidal saponins in plants

Y Li, H Yang, Z Li, S Li, J Li - International Journal of Molecular Sciences, 2023 - mdpi.com
Steroidal saponins are an important type of plant-specific metabolite that are essential for
plants' responses to biotic and abiotic stresses. Because of their extensive pharmacological …

Chromosome evolution and the genetic basis of agronomically important traits in greater yam

JV Bredeson, JB Lyons, IO Oniyinde… - Nature …, 2022 - nature.com
The nutrient-rich tubers of the greater yam, Dioscorea alata L., provide food and income
security for millions of people around the world. Despite its global importance, however …

Hyperproduction of 7-dehydrocholesterol by rewiring the post-squalene module in lipid droplets of Saccharomyces cerevisiae

X Xiu, X Xu, Y Wu, Y Liu, J Li, G Du, J Chen, X Lv… - Metabolic …, 2024 - Elsevier
Lipid droplets (LDs) are specialized organelles that store neutral lipids to reduce the
negative effects of lipotoxicity on cells. However, many neutral lipids are precursors for the …

Verazine biosynthesis from simple sugars in engineered Saccharomyces cerevisiae

PH Winegar, GA Hudson, LB Dell, MCT Astolfi… - Metabolic …, 2024 - Elsevier
Steroidal alkaloids are FDA-approved drugs (eg, Zytiga) and promising drug
candidates/leads (eg, cyclopamine); yet many of the≥ 697 known steroidal alkaloid natural …

Metabolic engineering of Saccharomyces cerevisiae for gram-scale diosgenin production

L Xu, D Wang, J Chen, B Li, Q Li, P Liu, Y Qin, Z Dai… - Metabolic …, 2022 - Elsevier
Diosgenin (DSG) is a naturally occurring steroidal saponin with a variety of biological
activities that is also an important precursor for the synthesis of various steroidal drugs. The …

The genome of Dioscorea zingiberensis sheds light on the biosynthesis, origin and evolution of the medicinally important diosgenin saponins

Y Li, C Tan, Z Li, J Guo, S Li, X Chen… - Horticulture …, 2022 - academic.oup.com
Diosgenin saponins isolated from Dioscorea species such as D. zingiberensis exhibit a
broad spectrum of pharmacological activities. Diosgenin, the aglycone of diosgenin …

Melatonin confers fenugreek tolerance to salinity stress by stimulating the biosynthesis processes of enzymatic, non-enzymatic antioxidants, and diosgenin content

M Mohamadi Esboei, A Ebrahimi… - Frontiers in Plant …, 2022 - frontiersin.org
Salinity-induced stress is widely considered a main plant-growth-limiting factor. The positive
effects of melatonin in modulating abiotic stresses have led this hormone to be referred to as …

Production of plant volatile terpenoids (rose oil) by yeast cell factories

R Li, K Wang, D Wang, L Xu, Y Shi, Z Dai, X Zhang - Green Chemistry, 2021 - pubs.rsc.org
Plant volatile terpenoids (PVTs) are the main aroma components of flowers, fruits, and
vegetables. Citronellol, geraniol, and nerol are the three major components of rose oil …

Intraspecific phylogeny and genomic resources development for an important medical plant Dioscorea nipponica, based on low-coverage whole genome sequencing …

K Hu, M Chen, P Li, X Sun, R Lu - Frontiers in Plant Science, 2023 - frontiersin.org
Dioscorea nipponica Makino, a perennial twining herb with medicinal importance, has a
disjunctive distribution in the Sino-Japanese Floristic Region. It has a long history in …