Cooperative Self‐Assembly of Pyridine‐2, 6‐Diimine‐Linked Macrocycles into Mechanically Robust Nanotubes

MJ Strauss, D Asheghali, AM Evans, RL Li… - Angewandte …, 2019 - Wiley Online Library
Nanotubes assembled from macrocyclic precursors offer a unique combination of low
dimensionality, structural rigidity, and distinct interior and exterior microenvironments …

Dynamics of microtubules: highlights of recent computational and experimental investigations

V Barsegov, JL Ross, RI Dima - Journal of Physics: Condensed …, 2017 - iopscience.iop.org
Microtubules are found in most eukaryotic cells, with homologs in eubacteria and archea,
and they have functional roles in mitosis, cell motility, intracellular transport, and the …

Anisotropic elastic network modeling of entire microtubules

MA Deriu, M Soncini, M Orsi, M Patel, JW Essex… - Biophysical journal, 2010 - cell.com
Microtubules are supramolecular structures that make up the cytoskeleton and strongly
affect the mechanical properties of the cell. Within the cytoskeleton filaments, the …

A comprehensive study on the electrostatic properties of tubulin-tubulin complexes in microtubules

W Guo, TA Ale, S Sun, JE Sanchez, L Li - Cells, 2023 - mdpi.com
Microtubules are key players in several stages of the cell cycle and are also involved in the
transportation of cellular organelles. Microtubules are polymerized by α/β tubulin dimers with …

Microtubules soften due to cross-sectional flattening

E Memet, F Hilitski, MA Morris, WJ Schwenger, Z Dogic… - Elife, 2018 - elifesciences.org
We use optical trapping to continuously bend an isolated microtubule while simultaneously
measuring the applied force and the resulting filament strain, thus allowing us to determine …

Deformation pattern in vibrating microtubule: Structural mechanics study based on an atomistic approach

D Havelka, MA Deriu, M Cifra, O Kučera - Scientific Reports, 2017 - nature.com
The mechanical properties of microtubules are of great importance for understanding their
biological function and for applications in artificial devices. Although microtubule mechanics …

Molecular structural mechanics model for the mechanical properties of microtubules

J Zhang, C Wang - Biomechanics and modeling in mechanobiology, 2014 - Springer
The aim of this paper was to develop a structural mechanics (SM) model for the microtubules
(MTs) in cells. The technique enables one to study the configuration effect on the …

Damage and failure of axonal microtubule under extreme high strain rate: an in-silico molecular dynamics study

YT Wu, A Adnan - Scientific reports, 2018 - nature.com
As a major cytoskeleton element of the axon, the breaking of microtubules (MTs) has been
considered as a major cause of the axon degeneration. High strain rate loading is …

Investigation of the Josephin domain protein-protein interaction by molecular dynamics

MA Deriu, G Grasso, G Licandro, A Danani, D Gallo… - PLoS …, 2014 - journals.plos.org
Spinocerebellar ataxia (SCA) 3, the most common form of SCA, is a neurodegenerative rare
disease characterized by polyglutamine tract expansion and self-assembly of Ataxin3 (At3) …

Coarse-grained mechanochemical model for simulating the dynamic behavior of microtubules

XY Ji, XQ Feng - Physical Review E—Statistical, Nonlinear, and Soft …, 2011 - APS
Modeling the structure and mechanics of microtubules, which play significant roles in
various physiological functions of cells, has long been a fascinating issue. In this paper, a …