Therapeutic options for pulmonary arterial hypertension (PAH) have increased over the last
decades. The advent of pharmacological therapies targeting the prostacyclin, endothelin …

Epigenetic mechanisms, including DNA methylation and histone post‐translational
modifications (PTMs), have been known to regulate chromatin structure and lineage‐specific …

Phenotypic alterations in resident vascular cells contribute to the vascular remodeling
process in diseases such as pulmonary (arterial) hypertension [P (A) H]. How the molecular …

Piezo is a mechanosensitive cation channel responsible for stretch-mediated Ca2+ and Na+
influx in multiple types of cells. Little is known about the functional role of Piezo1 in the lung …

ATP citrate lyase (ACLY), a crucial enzyme in de novo lipid synthesis and histone
acetylation, plays a key role in regulating vascular smooth muscle cell (VSMC) proliferation …

Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality
worldwide and encompasses chronic bronchitis and emphysema. It has been shown that …

The vasculature not only transports oxygenated blood, metabolites, and waste products but
also serves as a conduit for hormonal communication between distant tissues. Therefore, it …

In pulmonary arterial hypertension (PAH), the Warburg effect (glycolytic shift) and
mitochondrial fission are determinants of phenotype alterations characteristic of the disease …

Significance: The molecular events that promote the development of pulmonary
hypertension (PH) are complex and incompletely understood. The complex interplay …

Once perceived as a disorder treated by vasodilation, pulmonary artery hypertension (PAH)
has emerged as a pulmonary vascular disease with severe endothelial cell dysfunction. In …