Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

In high-, middle-and low-income countries, the rising prevalence of obesity is the underlying
cause of numerous health complications and increased mortality. Being a complex and …

Syndromic monogenic obesity typically follows Mendelian patterns of inheritance and
involves the co‐presentation of other characteristics, such as mental retardation, dysmorphic …

Obesity is a major public health concern. This condition results from a constant and complex
interplay between predisposing genes and environmental stimuli. Current attempts to …

While numerous studies have implicated copy number variants (CNVs) in a range of
neurological phenotypes, the impact relative to disease severity has been difficult to …

Prader-Willi syndrome (PWS) is characterized by severe hypotonia and feeding difficulties in
early infancy, followed in later infancy or early childhood by excessive eating and gradual …

The heritability of obesity has long been appreciated and the genetics of obesity has been
the focus of intensive study for decades. Early studies elucidating genetic factors involved in …

Abstract The Prader-Willi syndrome (PWS) is a human imprinting disorder resulting from
genomic alterations that inactivate imprinted, paternally expressed genes in human …

Steroid hormones are responsible for coordinating many aspects of biological processes in
most multicellular organisms, including insects. Ecdysteroid, the principal insect steroid …

Sim1 haploinsufficiency in mice induces hyperphagic obesity and developmental
abnormalities of the brain. In humans, abnormalities in chromosome 6q16, a region that …