Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …

Simple Summary The Hedgehog/GLI (Hh/GLI) pathway plays a major role during
development and it is commonly dysregulated in many diseases, including cancer. This …

The Hedgehog-GLI (HH-GLI) pathway is a highly conserved signaling that plays a critical
role in controlling cell specification, cell–cell interaction and tissue patterning during …

The hedgehog (HH) signaling pathway regulates normal cell growth and differentiation. As a
consequence of improper control, aberrant HH signaling results in tumorigenesis and …

Metastasis is crucial for the mortality of non-small cell lung carcinoma (NSCLC) patients. The
epithelial–mesenchymal transition (EMT) plays a critical role in regulating tumor metastasis …

It is well established that a subset of cells within primary breast cancers can undergo an
epithelial-to-mesenchymal transition (EMT), although the role of EMT in metastasis remains …

The hedgehog (Hh) pathway plays a key role in embryonic development and stem cell
programs. Deregulation of the Hh pathway is a key driver of basal cell carcinoma, and …

Cell identity is largely determined by its transcriptional profile. In tumour, deregulation of
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …

Hedgehog signals are transduced through Patched receptors to the Smoothened (SMO)-
SUFU-GLI and SMO-Gi-RhoA signaling cascades. MTOR-S6K1 and MEK-ERK signals are …

Medulloblastoma (MB) is a highly malignant cerebellar tumor predominantly diagnosed
during childhood. Driven by pathogenic activation of sonic hedgehog (SHH) signaling, SHH …