Multidrug resistance (MDR) is the dominant challenge in the failure of chemotherapy in
cancers. Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that spreads intracellular …

Cisplatin, carboplatin and oxaliplatin are platinum-based drugs that are widely used in
cancer chemotherapy. Platinum–DNA adducts, which are formed following uptake of the …

Cisplatin is one of the most effective anticancer agents widely used in the treatment of solid
tumors. It is generally considered as a cytotoxic drug which kills cancer cells by damaging …

Since the discovery by Rosenberg and collaborators of the antitumor activity of cisplatin 35
years ago, three platinum antitumor drugs (cisplatin, carboplatin and oxaliplatin) have …

Chemotherapy is one of the main therapeutic modalities for cancer patients. Cisplatin
(CDDP), as one of the first-line drugs, is of great importance in the chemotherapy of various …

Gynecological cancers are known for being very aggressive at their advanced stages.
Indeed, the survival rate of both ovarian and endometrial cancers is very low when …

Purpose: We aimed to find key molecules associated with chemoresistance in ovarian
cancer using gene expression profiling as a screening tool. Experimental Design: Using two …

The tumor suppressor p53 is important in the decision to either arrest cell cycle progression
or induce apoptosis in response to a variety of stimuli. p53 posttranslational modifications …

Curcumin, a major active component of turmeric, is known to induce apoptosis in several
types of cancer cells, but little is known about its activity in chemoresistant cells. Hence, the …

Apoptosis is a cell suicide mechanism that enables organisms to control cell number and
eliminate cells that threaten survival. The apoptotic cascade can be triggered through two …