Background It has been reported that diabetes mellitus affects 435 million people globally as
a primary health care problem. Despite many therapies available, many diabetes remains …

RNA-binding proteins (RBPs) are kinds of proteins with either singular or multiple RNA-
binding domains (RBDs), and they can assembly into ribonucleic acid–protein complexes …

Doxorubicin is one of the most important chemotherapeutic drugs for the treatment of
malignant tumors, but the cardiotoxicity of doxorubicin severely limits its clinical application …

Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are persistent organic
pollutants which may alter prenatal development, potentially through epigenetic …

A major fraction of loci identified by genome-wide association studies (GWASs) mediate
alternative splicing, but mechanistic interpretation is hindered by the technical limitations of …

RNA splicing is an important RNA processing step required by multiexon protein-coding
mRNAs and some noncoding RNAs. Precise RNA splicing is required for maintaining gene …

RBFOX2, which has a well-established role in alternative splicing, is linked to heart
diseases. However, it is unclear whether RBFOX2 has other roles in RNA processing that …

Alternative splicing allows a single gene to produce a variety of protein isoforms. Changes in
splicing isoform usage characterize virtually every stage of the differentiation process and …

Type 1 diabetes mellitus (T1DM) is a metabolic disorder for which the underlying molecular
mechanisms remain largely unclear. This investigation aimed to elucidate essential …

Objective: Calcium channel blockers, such as dihydropyridines, are commonly used to
inhibit enhanced activity of vascular CaV1. 2 channels in hypertension. However, patients …