The packaging of DNA into strings of nucleosomes is one of the features that allows
eukaryotic cells to tightly regulate gene expression. The ordered disassembly of …

Most histones are assembled into nucleosomes behind the replication fork to package newly
synthesized DNA. By contrast, histone variants, which are encoded by separate genes, are …

Histones package and compact DNA by assembling into nucleosome core particles. Most
histones are synthesized at S phase for rapid deposition behind replication forks. In addition …

In mammals, male germ cells differentiate from haploid round spermatids to flagella-
containing motile sperm, in a process called spermiogenesis. This process is distinct from …

Despite a conserved role for histones as general DNA packaging agents, it is now clear that
another key function of these proteins is to confer variations in chromatin structure to ensure …

Histone variants play crucial roles in gene expression, genome integrity, and chromosome
segregation. We report that the four H2A variants in Arabidopsis define different genomic …

Eukaryotic gene regulation involves a balance between packaging of the genome into
nucleosomes and enabling access to regulatory proteins and RNA polymerase …

Chromatin is of major relevance for gene expression, cell division, and differentiation. Here,
we determined the landscape of Arabidopsis thaliana chromatin states using 16 features …

Epigenetic reprogramming consists of global changes in DNA methylation and histone
modifications. In mammals, epigenetic reprogramming is primarily associated with sexual …

Understanding how to recover fully functional and transcriptionally active chromatin when its
integrity has been challenged by genotoxic stress is a critical issue. Here, by investigating …