Wolbachia as translational science: controlling mosquito-borne pathogens

EP Caragata, HLC Dutra, PHF Sucupira… - Trends in …, 2021 - cell.com
In this review we examine how exploiting the Wolbachia–mosquito relationship has become
an increasingly popular strategy for controlling arbovirus transmission. Field deployments of …

Using Wolbachia to Eliminate Dengue: Will the Virus Fight Back?

KM Edenborough, HA Flores, CP Simmons… - Journal of …, 2021 - Am Soc Microbiol
Recent field trials have demonstrated that dengue incidence can be substantially reduced
by introgressing strains of the endosymbiotic bacterium Wolbachia into Aedes aegypti …

[HTML][HTML] A decade of stability for wMel Wolbachia in natural Aedes aegypti populations

PA Ross, KL Robinson, Q Yang, AG Callahan… - PLoS …, 2022 - journals.plos.org
Mosquitoes carrying Wolbachia endosymbionts are being released in many countries for
arbovirus control. The wMel strain of Wolbachia blocks Aedes-borne virus transmission and …

A wAlbB Wolbachia Transinfection Displays Stable Phenotypic Effects across Divergent Aedes aegypti Mosquito Backgrounds

PA Ross, X Gu, KL Robinson, Q Yang… - Applied and …, 2021 - Am Soc Microbiol
Aedes mosquitoes harboring intracellular Wolbachia bacteria are being released in
arbovirus and mosquito control programs. With releases taking place around the world …

Genome evolution of dengue virus serotype 1 under selection by Wolbachia pipientis in Aedes aegypti mosquitoes

D Thi Hue Kien, K Edenborough… - Virus …, 2023 - academic.oup.com
The introgression of antiviral strains of Wolbachia into Aedes aegypti mosquito populations
is a public health intervention for the control of dengue. Plausibly, dengue virus (DENV) …

Designing effective Wolbachia release programs for mosquito and arbovirus control

PA Ross - Acta tropica, 2021 - Elsevier
Mosquitoes carrying endosymbiotic bacteria called Wolbachia are being released in
mosquito and arbovirus control programs around the world through two main approaches …

A wMel Wolbachia variant in Aedes aegypti from field‐collected Drosophila melanogaster with increased phenotypic stability under heat stress

X Gu, PA Ross, J Rodriguez‐Andres… - Environmental …, 2022 - Wiley Online Library
Mosquito‐borne diseases remain a major cause of morbidity and mortality. Population
replacement strategies involving the w Mel strain of Wolbachia are being used widely to …

Fitness costs of Wolbachia shift in locally‐adapted Aedes aegypti mosquitoes

PA Ross, AA Hoffmann - Environmental Microbiology, 2022 - Wiley Online Library
Aedes aegypti mosquito eggs can remain quiescent for many months before hatching,
allowing populations to persist through unfavourable conditions. A. aegypti infected with the …

wMel Wolbachia genome remains stable after 7 years in Australian Aedes aegypti field populations

KR Dainty, J Hawkey, LM Judd… - Microbial …, 2021 - microbiologyresearch.org
Infection of w Mel Wolbachia in Aedes aegypti imparts two signature features that enable its
application for biocontrol of dengue. First, the susceptibility of mosquitoes to viruses such as …

Post-release monitoring pathway for the deployment of gene drive-modified mosquitoes for malaria control in Africa

DO Ogoyi, J Njagi, W Tonui, B Dass, H Quemada… - Malaria Journal, 2024 - Springer
Background Gene drive-modified mosquitoes (GDMMs) have been promoted as one of the
innovative technologies that may control and eliminate malaria and other mosquito-borne …