Although nerve cell death is the hallmark of many neurological diseases, the processes
underlying this death are still poorly defined. However, there is a general consensus that …

This review is directed at understanding how neuronal death occurs in two distinct insults,
global ischemia and focal ischemia. These are the two principal rodent models for human …

Microtubule-associated protein 2 (MAP2) is the predominant cytoskeletal regulator within
neuronal dendrites, abundant and specific enough to serve as a robust somatodendritic …

Zinc is present in presynaptic nerve terminals throughout the mammalian central nervous
system and likely serves as an endogenous signaling substance. However, excessive …

In the human brain and spinal cord, neurons degenerate after acute insults (eg, stroke,
cardiac arrest, trauma) and during progressive, adult-onset diseases [eg, amyotrophic lateral …

The abnormal influx of Ca 2+ through glutamate receptor channels is thought to contribute to
the loss of neurons associated with a number of brain disorders. Until recently, the NMDA …

Programmed cell death (apoptosis) is a normal process in the developing nervous system.
Recent data suggest that certain features seen in the process of programmed cell death may …

Cells die by one of two mechanisms, necrosis or programmed cell death. Necrosis has been
implicated in stroke and occurs when the cytoplasmic membrane is compromised …

Neuronal death is normal during nervous system development but is abnormal in brain and
spinal cord disease and injury. Apoptosis and necrosis are types of cell death. They are …

Huntington disease (HD) is an inherited neurodegenerative disorder characterized by
selective death of striatal medium spiny neurons. Intrastriatal injections of glutamate receptor …