Major progress has been made in defining the basis of the mitochondrial permeability
transition, a Ca2+‐dependent permeability increase of the inner membrane that has puzzled …

The mitochondrial permeability transition (PT) is a permeability increase of the inner
mitochondrial membrane mediated by a channel, the permeability transition pore (PTP) …

Acute kidney injury (AKI) is the leading cause of nephrology consultation and is associated
with high mortality rates. The primary causes of AKI include ischemia, hypoxia or …

Here we define the molecular nature of the mitochondrial permeability transition pore (PTP),
a key effector of cell death. The PTP is regulated by matrix cyclophilin D (CyPD), which also …

In the last 5 years, most of the molecules that control mitochondrial Ca2+ homeostasis have
been finally identified. Mitochondrial Ca2+ uptake is mediated by the Mitochondrial Calcium …

This article reviews the involvement of the mitochondrial permeability transition pore in
necrotic and apoptotic cell death. The pore is formed from a complex of the voltage …

Changes in mitochondrial morphology that occur during cell cycle, differentiation, and death
are tightly regulated by the balance between fusion and fission processes. Excessive …

Hematopoietic stem cells (HSCs) reside in hypoxic niches within bone marrow and cord
blood. Yet, essentially all HSC studies have been performed with cells isolated and …

This review provides a selective history of how studies of mitochondrial cation transport (K+,
Na+, Ca2+) developed in relation to the major themes of research in bioenergetics. It then …

The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …