Abstract tRNAs are key partners in ribosome-dependent protein synthesis. This process is
highly dependent on the fidelity of tRNA aminoacylation by aminoacyl-tRNA synthetases …

RNA structure plays roles in myriad cellular events including transcription, translation, and
RNA processing. Genome-wide analyses of RNA secondary structure in vivo by chemical …

In this review, we describe the creation of the Nucleic Acid Database (NDB) at Rutgers
University and how it became a testbed for the current infrastructure of the RCSB Protein …

Abstract Poly (UG) or 'pUG'dinucleotide repeats are highly abundant sequences in
eukaryotic RNAs. In Caenorhabditis elegans, pUGs are added to RNA 3′ ends to direct …

Compartmentalization of RNA in biopolymer-rich membraneless organelles is now
understood to be pervasive and critical for the function of extant biology and has been …

Transfer RNAs undergo diverse posttranscriptional modifications to regulate a myriad of
cellular events including translation, stress response, and viral replication. These …

MazEF Toxin-antitoxin (TA) systems are associated with the persistent phenotype of the
pathogen, Mycobacterium tuberculosis (Mtb), aiding their survival. Though extensively …

The dynamic conformation of RNA molecules within living cells is key to their function.
Recent advances in probing the RNA structurome in vivo, including the use of SHAPE …

Aminoacyl-tRNA synthetases (aaRS) are ubiquitous enzymes responsible for aminoacyl-
tRNA (aa-tRNA) synthesis. Correctly formed aa-tRNAs are necessary for proper decoding of …

Summary The Piwi-interacting RNA (piRNA) pathway safeguards genomic integrity by
silencing transposable elements (transposons) in the germline. While Piwi is the central …