As the home of cellular genetic information, the nucleus has a critical role in determining cell
fate and function in response to various signals and stimuli. In addition to biochemical …

Living cells are constantly exposed to mechanical stimuli arising from the surrounding
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …

Recent evidence clearly shows that cells respond to various physical cues in their
environments, guiding many cellular processes and tissue morphogenesis, pathology, and …

Size control is fundamental in tissue development and homeostasis,. Although the role of
cell proliferation in these processes has been widely studied, the mechanisms that control …

Technological advancements in research on circulating biomarkers from patient derived
blood have enabled a less invasive means of diagnosing non-hematologic cancers …

The cell nucleus must continually resist and respond to intercellular and intracellular
mechanical forces to transduce mechanical signals and maintain proper genome …

Targeting the delivery of therapeutics specifically to diseased tissue enhances their efficacy
and decreases their side effects. Here we show that mesenchymal stromal cells with their …

Signals from the microenvironment around a cell are known to influence cell behavior.
Material properties, such as biochemical composition and substrate stiffness, are today …

Cells sense mechanical signals from their microenvironment and transduce them to the
nucleus to regulate gene expression programs. To elucidate the physical mechanisms …

Cells generate and sustain mechanical forces within their environment as part of their
normal physiology. They are active materials that can detect mechanical stimulation by the …