Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor
featuring rapid cell proliferation, treatment resistance, and tumor relapse. This is largely due …

Abstract Tuberous Sclerosis Complex (TSC) is caused by TSC1 or TSC2 mutations,
resulting in hyperactivation of the mechanistic target of rapamycin complex 1 (mTORC1) …

Autophagy is a process essential for cellular energy consumption, survival, and defense
mechanisms. The role of autophagy in several types of human cancers has been explicitly …

Background Endothelial oxidative injury is a key event in the pathogenesis of
atherosclerosis (AS). Resveratrol (RSV) attenuates the oxidative injury in human umbilical …

The discovery that mammalian target of rapamycin (mTOR) inhibition increases lifespan in
mice and restores/delays many aging phenotypes has led to the identification of a novel …

Glioblastoma (GBM) is the most aggressive malignant glioma and most lethal form of human
brain cancer (Clin J Oncol Nurs. 2016; 20: S2). GBM is also one of the most expensive and …

Nonalcoholic fatty liver disease (NAFLD), which is characterized by disruption of lipid
homeostasis, has been the leading cause of chronic liver disease worldwide. However …

The mechanistic target of rapamycin (mTOR), a serine-threonine kinase, plays a pivotal role
in regulating cell growth and proliferation. Notably, a great deal of evidence indicates that …

Doxorubicin (Dox) is an effective anti-cancer agent, whose clinical use is limited by the
cytotoxicity in non-target tissues, especially the heart and brain. The drug-induced neuronal …

Transcription factor EB (TFEB) belongs to the microphthalmia family of bHLH‐leucine zipper
transcription factors and was first identified as an oncogene in a subset of renal cell …