[HTML][HTML] Detection of viral infections by innate immunity
Pattern recognition receptors (PRRs) and inflammasomes are a key part of the anti-viral
innate immune system as they detect conserved viral pathogen-associated molecular …
innate immune system as they detect conserved viral pathogen-associated molecular …
Pathogenesis and virulence of herpes simplex virus
S Zhu, A Viejo-Borbolla - Virulence, 2021 - Taylor & Francis
Two of the most prevalent human viruses worldwide, herpes simplex virus type 1 and type 2
(HSV-1 and HSV-2, respectively), cause a variety of diseases, including cold sores, genital …
(HSV-1 and HSV-2, respectively), cause a variety of diseases, including cold sores, genital …
AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence
Inflammasomes are important sentinels of innate immune defence, sensing pathogens and
inducing cell death in infected cells. There are several inflammasome sensors that each …
inducing cell death in infected cells. There are several inflammasome sensors that each …
AIM2 in health and disease: Inflammasome and beyond
P Kumari, AJ Russo, S Shivcharan… - Immunological …, 2020 - Wiley Online Library
Nucleic acid sensing is a critical mechanism by which the immune system monitors for
pathogen invasion. A set of germline‐encoded innate immune receptors detect microbial …
pathogen invasion. A set of germline‐encoded innate immune receptors detect microbial …
Role of AIM2 inflammasome in inflammatory diseases, cancer and infection
AIM2 is a cytosolic innate immune receptor which recognizes double‐stranded DNA
(dsDNA) released during cellular perturbation and pathogenic assault. AIM2 recognition of …
(dsDNA) released during cellular perturbation and pathogenic assault. AIM2 recognition of …
The race between host antiviral innate immunity and the immune evasion strategies of herpes simplex virus 1
H Zhu, C Zheng - Microbiology and Molecular Biology Reviews, 2020 - Am Soc Microbiol
SUMMARY Herpes simplex virus 1 (HSV-1) is very successful in establishing acute and
latent infections in humans by counteracting host antiviral innate immune responses. HSV-1 …
latent infections in humans by counteracting host antiviral innate immune responses. HSV-1 …
The inflammasome in times of COVID-19
Coronaviruses (CoVs) are members of the genus Betacoronavirus and the Coronaviridiae
family responsible for infections such as severe acute respiratory syndrome (SARS), Middle …
family responsible for infections such as severe acute respiratory syndrome (SARS), Middle …
STING promotes NLRP3 localization in ER and facilitates NLRP3 deubiquitination to activate the inflammasome upon HSV-1 infection
W Wang, D Hu, C Wu, Y Feng, A Li, W Liu… - PLoS …, 2020 - journals.plos.org
One of the fundamental reactions of the innate immune responses to pathogen infection is
the release of pro-inflammatory cytokines, including IL-1β, processed by the NLRP3 …
the release of pro-inflammatory cytokines, including IL-1β, processed by the NLRP3 …
The antisocial network: cross talk between cell death programs in host defense
AG Snyder, A Oberst - Annual review of immunology, 2021 - annualreviews.org
Nearly all animal cells contain proteins evolved to trigger the destruction of the cell in which
they reside. The activation of these proteins occurs via sequential programs, and much effort …
they reside. The activation of these proteins occurs via sequential programs, and much effort …
DNA sensing in the innate immune response
The innate immune system recognizes conserved pathogen-associated molecular patterns
and produces inflammatory cytokines that direct downstream immune responses. The …
and produces inflammatory cytokines that direct downstream immune responses. The …