Origins of HIV and the AIDS pandemic

PM Sharp, BH Hahn - Cold Spring …, 2011 - perspectivesinmedicine.cshlp.org
Acquired immunodeficiency syndrome (AIDS) of humans is caused by two lentiviruses,
human immunodeficiency viruses types 1 and 2 (HIV-1 and HIV-2). Here, we describe the …

Factors in the emergence of infectious diseases.

SS Morse - Emerging infectious diseases, 1995 - ncbi.nlm.nih.gov
Abstract" Emerging" infectious diseases can be defined as infections that have newly
appeared in a population or have existed but are rapidly increasing in incidence or …

Evasion of cGAS and TRIM5 defines pandemic HIV

L Zuliani-Alvarez, ML Govasli, J Rasaiyaah… - Nature …, 2022 - nature.com
Of the 13 known independent zoonoses of simian immunodeficiency viruses to humans,
only one, leading to human immunodeficiency virus (HIV) type 1 (M) has become pandemic …

Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes

F Gao, E Bailes, DL Robertson, Y Chen… - Nature, 1999 - nature.com
The human AIDS viruses human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2)
represent cross-species (zoonotic) infections,,,. Although the primate reservoir of HIV-2 has …

How does HIV cause AIDS?

RA Weiss - Science, 1993 - science.org
Many questions have been posed about acquired immunodeficiency syndrome (AIDS)
pathogenesis. Is human immunodeficiency virus (HIV) both necessary and sufficient to …

AIDS as a zoonosis: scientific and public health implications

BH Hahn, GM Shaw, KM De, Cock, PM Sharp - Science, 2000 - science.org
Evidence of simian immunodeficiency virus (SIV) infection has been reported for 26 different
species of African nonhuman primates. Two of these viruses, SIVcpz from chimpanzees and …

Timing the ancestor of the HIV-1 pandemic strains

B Korber, M Muldoon, J Theiler, F Gao, R Gupta… - science, 2000 - science.org
HIV-1 sequences were analyzed to estimate the timing of the ancestral sequence of the
main group of HIV-1, the strains responsible for the AIDS pandemic. Using parallel …

Pathogenesis of human immunodeficiency virus infection

JA Levy - Microbiological reviews, 1993 - Am Soc Microbiol
The lentivirus human immunodeficiency virus (HIV) causes AIDS by interacting with a large
number of different cells in the body and escaping the host immune response against it. HIV …

Genetic diversity and evolution of hepatitis C virus–15 years on

P Simmonds - Journal of General Virology, 2004 - microbiologyresearch.org
In the 15 years since the discovery of hepatitis C virus (HCV), much has been learned about
its role as a major causative agent of human liver disease and its ability to persist in the face …

The evolution of HIV-1 and the origin of AIDS

PM Sharp, BH Hahn - … of the Royal Society B: Biological …, 2010 - royalsocietypublishing.org
The major cause of acquired immune deficiency syndrome (AIDS) is human
immunodeficiency virus type 1 (HIV-1). We have been using evolutionary comparisons to …