Enteroviruses are believed to trigger or accelerate islet autoimmunity in genetically
susceptible individuals, thereby resulting in loss of functional insulin-producing β-cells and …

Interferon-stimulated gene (ISG) products take on a number of diverse roles. Collectively,
they are highly effective at resisting and controlling pathogens. In this review, we begin by …

The type I interferon response protects cells against invading viral pathogens. The cellular
factors that mediate this defence are the products of interferon-stimulated genes (ISGs) …

Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease with a strong
inflammatory component. The latest studies indicate that innate immunity and inflammatory …

Current methods for comparing single-cell RNA sequencing datasets collected in multiple
conditions focus on discrete regions of the transcriptional state space, such as clusters of …

Enteroviruses are believed to contribute to the pathogenesis of type 1 diabetes mellitus
(T1DM). In this Review, the interplay between infection with enteroviruses, the immune …

Rapid and robust induction of type I IFN (IFN-I) is a critical event in host antiviral innate
immune response. It has been well demonstrated that cyclic GMP-AMP (cGAMP) synthase …

Highlights•Enteroviral infection has been long-associated with type 1 diabetes in
epidemiological studies.•β-Cells express a specific enteroviral receptor isoform, CAR-SIV …

Genome‐wide association studies (GWAS) have identified more than 50 loci associated with
genetic risk of type 1 diabetes (T1D). Several T1D candidate genes have been suggested or …

OBJECTIVE Fulminant type 1 diabetes is characterized by the rapid onset of severe
hyperglycemia and ketoacidosis, with subsequent poor prognosis of diabetes complications …