N6-methyladenosine-mediated gene regulation and therapeutic implications
Abstract N6-methyladenosine (m 6 A) RNA methylation is the most abundant form of mRNA
modification in eukaryotes and is at the front line of biological and biomedical research. This …
modification in eukaryotes and is at the front line of biological and biomedical research. This …
Coding, or non-coding, that is the question
L Poliseno, M Lanza, PP Pandolfi - Cell Research, 2024 - nature.com
The advent of high-throughput sequencing uncovered that our genome is pervasively
transcribed into RNAs that are seemingly not translated into proteins. It was also found that …
transcribed into RNAs that are seemingly not translated into proteins. It was also found that …
R-loops' m6A modification and its roles in cancers
Y Qiu, C Man, L Zhu, S Zhang, X Wang, D Gong… - Molecular Cancer, 2024 - Springer
R-loops are three-stranded nucleic acid structures composed of an RNA–DNA hybrid and a
displaced DNA strand. They are widespread and play crucial roles in regulating gene …
displaced DNA strand. They are widespread and play crucial roles in regulating gene …
Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions
Here, in a multi-ancestry genome-wide association study meta-analysis of kidney cancer
(29,020 cases and 835,670 controls), we identified 63 susceptibility regions (50 novel) …
(29,020 cases and 835,670 controls), we identified 63 susceptibility regions (50 novel) …
[HTML][HTML] Competing endogenous RNAs (ceRNAs) and drug resistance to cancer therapy
Competing endogenous RNAs (ceRNAs) are transcripts that possess highly similar
microRNA response elements (MREs). microRNAs (miRNAs) are short, endogenous, single …
microRNA response elements (MREs). microRNAs (miRNAs) are short, endogenous, single …
[HTML][HTML] YY1 is regulated by ALKBH5-mediated m6A modification and promotes autophagy and cancer progression through targeting ATG4B
S Wang, J Nie, K Xu, Y Liu, W Tong, A Li, W Zuo… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
YY1 affects tumorigenesis and metastasis in multiple ways. However, the function of YY1
and the potential mechanisms through which it operates in gastric cancer (GC) progression …
and the potential mechanisms through which it operates in gastric cancer (GC) progression …
The role of ADAR1 through and beyond its editing activity in cancer
Y Jiao, Y Xu, C Liu, R Miao, C Liu, Y Wang… - Cell Communication and …, 2024 - Springer
Abstract Adenosine-to-inosine (A-to-I) editing of RNA, catalyzed by adenosine deaminase
acting on RNA (ADAR) enzymes, is a prevalent RNA modification in mammals. It has been …
acting on RNA (ADAR) enzymes, is a prevalent RNA modification in mammals. It has been …
Roles for epithelial integrin α3β1 in regulation of the microenvironment during normal and pathological tissue remodeling
RP Miskin, CM DiPersio - American Journal of Physiology …, 2024 - journals.physiology.org
Integrin receptors for the extracellular matrix activate intracellular signaling pathways that
are critical for tissue development, homeostasis, and regeneration/repair, and their loss or …
are critical for tissue development, homeostasis, and regeneration/repair, and their loss or …
Autoimmune disease: A view of epigenetics and therapeutic targeting
S Mu, W Wang, Q Liu, N Ke, H Li, F Sun… - Frontiers in …, 2024 - frontiersin.org
Autoimmune diseases comprise a large group of conditions characterized by a complex
pathogenesis and significant heterogeneity in their clinical manifestations. Advances in …
pathogenesis and significant heterogeneity in their clinical manifestations. Advances in …
[HTML][HTML] 3'UTR diversity: expanding repertoire of RNA alterations in human mRNAs
D Hong, S Jeong - Molecules and cells, 2023 - Elsevier
Genomic information stored in the DNA is transcribed to the mRNA and translated to
proteins. The 3′ untranslated regions (3′ UTRs) of the mRNA serve pivotal roles in post …
proteins. The 3′ untranslated regions (3′ UTRs) of the mRNA serve pivotal roles in post …