Ever since the brain was identified as an insulin-sensitive organ, evidence has rapidly
accumulated that insulin action in the brain produces multiple behavioral and metabolic …

Background: Millions of patients are discharged from intensive care units annually. These
intensive care survivors and their families frequently report a wide range of impairments in …

Stress hyperglycemia is common in critically ill patients and appears to be a marker of
disease severity. Furthermore, both the admission as well as the mean glucose level during …

Objectives: As critical care advances and intensive care unit mortality declines, the number
of survivors of critical illness is increasing. These survivors frequently experience long …

Critically ill patients frequently experience poor sleep, characterized by frequent disruptions,
loss of circadian rhythms, and a paucity of time spent in restorative sleep stages. Factors that …

The modern era of sepsis management is characterised by a growing number of patients
who survive in the short term and are discharged from hospital. Increasing evidence …

It has long been established that stress has a significant impact on metabolic function. Type
2 diabetes may be initiated by psychological and physical stress. The central and peripheral …

Introduction Post-intensive care syndrome (PICS) has only recently been recognized as a
new clinical entity in patients surviving their intensive care unit (ICU) stay due to critical …

Long-term cognitive impairment is common among ICU survivors, but its natural history
remains unclear. In this systematic review, we report the frequency of cognitive impairment …

In contrast to other clinical outcomes, long-term cognitive function in critical care survivors
has not been deeply studied. In this narrative review, we summarize the existing literature on …