Nerve growth factor signaling and its contribution to pain
Nerve growth factor (NGF) is a neurotrophic protein essential for the growth, differentiation,
and survival of sympathetic and sensory afferent neurons during development. A substantial …
and survival of sympathetic and sensory afferent neurons during development. A substantial …
Challenges and opportunities in translational pain research–An opinion paper of the working group on translational pain research of the European pain federation …
For decades, basic research on the underlying mechanisms of nociception has held promise
to translate into efficacious treatments for patients with pain. Despite great improvement in …
to translate into efficacious treatments for patients with pain. Despite great improvement in …
End points for sickle cell disease clinical trials: patient-reported outcomes, pain, and the brain
AT Farrell, J Panepinto, CP Carroll, DS Darbari… - Blood …, 2019 - ashpublications.org
To address the global burden of sickle cell disease (SCD) and the need for novel therapies,
the American Society of Hematology partnered with the US Food and Drug Administration to …
the American Society of Hematology partnered with the US Food and Drug Administration to …
Mechanisms and manifestations in musculoskeletal pain: from experimental to clinical pain settings
T Graven-Nielsen - Pain, 2022 - journals.lww.com
Musculoskeletal pain is an extensive societal challenge, due to the large population
affected, an increased expected life span, and the lack of efficient prevention and treatment …
affected, an increased expected life span, and the lack of efficient prevention and treatment …
Assessment of conditioned pain modulation in healthy participants and patients with chronic pain: manifestations and implications for pain progression
As CPM methodology is optimized, studies are revealing factors that can modulate
descending pain inhibitory pathways. Understanding underlying mechanisms of CPM will …
descending pain inhibitory pathways. Understanding underlying mechanisms of CPM will …
[HTML][HTML] The effect of acute and sustained pain on corticomotor excitability: a systematic review and meta-analysis of group and individual level data
Pain alters motor function. This is supported by studies showing reduced corticomotor
excitability in response to experimental pain lasting< 90 minutes. Whether similar reductions …
excitability in response to experimental pain lasting< 90 minutes. Whether similar reductions …
Disrupted cortical homeostatic plasticity due to prolonged capsaicin-induced pain
PG Wittkopf, DB Larsen, L Gregoret, T Graven-Nielsen - Neuroscience, 2023 - Elsevier
Homeostatic plasticity (HP) regulates cortical excitability (CE) stability but is disrupted in
persistent pain conditions. This study investigated how prolonged experimental pain affects …
persistent pain conditions. This study investigated how prolonged experimental pain affects …
High frequency repetitive transcranial magnetic stimulation to the left dorsolateral prefrontal cortex modulates sensorimotor cortex function in the transition to sustained …
Based on reciprocal connections between the dorsolateral prefrontal cortex (DLPFC) and
basal-ganglia regions associated with sensorimotor cortical excitability, it was hypothesized …
basal-ganglia regions associated with sensorimotor cortical excitability, it was hypothesized …
[HTML][HTML] Slowing in peak-alpha frequency recorded after experimentally-induced muscle pain is not significantly different between high and low pain-sensitive subjects
E De Martino, L Gregoret, M Zandalasini… - The Journal of …, 2021 - Elsevier
Peak alpha frequency (PAF) reduces during cutaneous pain, but no studies have
investigated PAF during movement-related muscle pain. Whether high-pain sensitive (HPS) …
investigated PAF during movement-related muscle pain. Whether high-pain sensitive (HPS) …
[HTML][HTML] Corticomotor depression is associated with higher pain severity in the transition to sustained pain: a longitudinal exploratory study of individual differences
Aberrant motor cortex plasticity is hypothesized to contribute to chronic musculoskeletal
pain, but evidence is limited. Critically, studies have not considered individual differences in …
pain, but evidence is limited. Critically, studies have not considered individual differences in …