Knowns and unknowns about CAR-T cell dysfunction
Simple Summary The primary issue of adoptive cell therapy is the poor in vivo persistence.
In this context, it is necessary to clarify the fundamental mechanisms of T cell dysfunction …
In this context, it is necessary to clarify the fundamental mechanisms of T cell dysfunction …
Clonal lineage tracing reveals mechanisms skewing CD8+ T cell fate decisions in chronic infection
Although recent evidence demonstrates heterogeneity among CD8+ T cells during chronic
infection, developmental relationships and mechanisms underlying their fate decisions …
infection, developmental relationships and mechanisms underlying their fate decisions …
Single-cell transcriptome profiling and chromatin accessibility reveal an exhausted regulatory CD4+ T cell subset in systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease, and CD4+ T cells
are known to promote SLE development. Here, we explore heterogeneities in the CD4+ T …
are known to promote SLE development. Here, we explore heterogeneities in the CD4+ T …
Post-translational modification of MALT1 and its role in B cell-and T cell-related diseases
YY Zhang, J Peng, XJ Luo - Biochemical Pharmacology, 2022 - Elsevier
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is a
multifunctional protein. MALT1 functions as an adaptor protein to assemble and recruit …
multifunctional protein. MALT1 functions as an adaptor protein to assemble and recruit …
[HTML][HTML] Human epigenetic and transcriptional T cell differentiation atlas for identifying functional T cell-specific enhancers
The clinical benefit of T cell immunotherapies remains limited by incomplete understanding
of T cell differentiation and dysfunction. We generated an epigenetic and transcriptional …
of T cell differentiation and dysfunction. We generated an epigenetic and transcriptional …
RBM15-mediated N6-methyladenosine modification affects COVID-19 severity by regulating the expression of multitarget genes
Y Meng, Q Zhang, K Wang, X Zhang, R Yang, K Bi… - Cell death & …, 2021 - nature.com
Abstract Severe coronavirus disease 2019 (COVID-19) is characterized by symptoms of
lymphopenia and multiorgan damage, but the underlying mechanisms remain unclear. To …
lymphopenia and multiorgan damage, but the underlying mechanisms remain unclear. To …
Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4
S Grosche, I Marenholz, J Esparza-Gordillo… - Nature …, 2021 - nature.com
Previous genome-wide association studies revealed multiple common variants involved in
eczema but the role of rare variants remains to be elucidated. Here, we investigate the role …
eczema but the role of rare variants remains to be elucidated. Here, we investigate the role …
[HTML][HTML] The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR+ CD8+ effector state, and its deletion improves checkpoint blockade
Summary CD8+ T cell exhaustion (T EX) impairs the ability of T cells to clear chronic
infection or cancer. While T EX are hypofunctional, some T EX retain effector gene …
infection or cancer. While T EX are hypofunctional, some T EX retain effector gene …
Rapid increase of C/EBPα p42 induces growth arrest of acute myeloid leukemia (AML) cells by Cop1 deletion in Trib1-expressing AML
Y Sunami, S Yoshino, Y Yamazaki, T Iwamoto… - Leukemia, 2024 - nature.com
Cop1 encodes a ubiquitin E3 ligase that has been well preserved during evolution in both
plants and metazoans. In metazoans, the C/EBP family transcription factors are targets for …
plants and metazoans. In metazoans, the C/EBP family transcription factors are targets for …
Structure vs. Function of trib1—myeloid neoplasms and beyond
Simple Summary Tribbles proteins possess the structure of protein kinases but function by
forming protein complexes rather than phosphorylating substrates. Here we review the …
forming protein complexes rather than phosphorylating substrates. Here we review the …