Glycans, carbohydrate molecules in the realm of biology, are present as biomedically
important glycoconjugates and a characteristic aspect is that their structures in many …

Glycosylation is the most abundant and complex protein modification, and can have a
profound structural and functional effect on the conjugate. The oligosaccharide fraction is …

Highlights•NMR methods are of paramount importance to deduce structure, dynamics and
recognition of complex glycans.•The intrinsic low sensitivity of NMR for studying glycans and …

Posttranslational modifications are an important feature of most proteases in higher
organisms, such as the conversion of inactive zymogens into active proteases. To date, little …

This perspective article is focused on the presentation of the latest advances in NMR
methods and applications that are behind the exciting achievements in the understanding of …

Regulatory bodies worldwide consider N-glycosylation to be a critical quality attribute for
immunoglobulin G (IgG) and IgG-like therapeutics. This consideration is due to the …

Bacterial pathogens have evolved intricate mechanisms to evade the human immune
system, including the production of immunomodulatory enzymes. Streptococcus pyogenes …

The diversity of the cellular proteome substantially exceeds the number of genes coded by
the DNA of an organism because one or more residues in a majority of eukaryotic proteins …

Abstract Nuclear Magnetic Resonance (NMR) spectra of human serum and plasma show,
besides metabolites and lipoproteins, two characteristic signals termed GlycA and B arising …

Understanding the dynamics of protein–ligand interactions, which lie at the heart of host–
pathogen recognition, represents a crucial step to clarify the molecular determinants …