Reconstitution of T cell subsets following allogeneic hematopoietic cell transplantation

L Dekker, C de Koning, C Lindemans, S Nierkens - Cancers, 2020 - mdpi.com
Allogeneic (allo) hematopoietic cell transplantation (HCT) is the only curative treatment
option for patients suffering from chemotherapy-refractory or relapsed hematological …

Biomarkers for early complications post hematopoietic cell transplantation: Insights and challenges

B Balakrishnan, UP Kulkarni, AA Pai… - Frontiers in …, 2023 - frontiersin.org
Hematopoietic cell transplantation is an established curative treatment option for various
hematological malignant, and non-malignant diseases. However, the success of HCT is still …

Naive T cells in graft versus host disease and graft versus leukemia: innocent or guilty?

L Dekker, E Sanders, CA Lindemans… - Frontiers in …, 2022 - frontiersin.org
The outcome of allogeneic hematopoietic cell transplantation (allo-HCT) largely depends on
the development and management of graft-versus-host disease (GvHD), infections, and the …

The complex existence of γδ T cells following transplantation: the good, the bad and the simply confusing

LC Sullivan, EM Shaw, S Stankovic… - Clinical & …, 2019 - Wiley Online Library
Gamma delta (γδ) T cells are a highly heterogeneous population of lymphocytes that exhibit
innate and adaptive immune properties. Despite comprising the majority of residing …

CD8+γδ T Cells Are More Frequent in CMV Seropositive Bone Marrow Grafts and Display Phenotype of an Adaptive Immune Response

A Gaballa, LCM Arruda, E Rådestad… - Stem Cells …, 2019 - Wiley Online Library
The role of gamma delta (γδ) T cells in human cytomegalovirus (HCMV) immune
surveillance has been the focus of research interest for years. Recent reports have shown a …

Graft γδ TCR sequencing identifies public clonotypes associated with hematopoietic stem cell transplantation efficacy in acute myeloid leukemia patients and unravels …

L Arruda, A Gaballa, M Uhlin - The Journal of Immunology, 2019 - journals.aai.org
Although the impact of donor graft composition on clinical outcomes after hematopoietic
stem cell transplantation (HSCT) has been studied, little is known about the role of intragraft …

CD69+ resident memory T cells are associated with graft‐versus‐host disease in intestinal transplantation

J Weiner, N Svetlicky, J Kang, M Sadat… - American Journal of …, 2021 - Wiley Online Library
Graft‐versus‐host disease (GvHD) is a common, morbid complication after intestinal
transplantation (ITx) with poorly understood pathophysiology. Resident memory T cells …

T-cell frequencies of CD8+ γδ and CD27+ γδ cells in the stem cell graft predict the outcome after allogeneic hematopoietic cell transplantation

A Gaballa, A Stikvoort, B Önfelt, J Mattsson… - Bone Marrow …, 2019 - nature.com
The impact of intra-graft T cells on the clinical outcome after allogeneic hematopoietic cell
transplantation has been investigated. Most previous studies have focused on the role of αβ …

Association between P2X7 polymorphisms and post-transplant outcomes in allogeneic haematopoietic stem cell transplantation

RM Koldej, T Perera, J Collins, DS Ritchie - International Journal of …, 2020 - mdpi.com
Allogeneic stem cell transplantation (alloSCT) is a highly effective treatment method for
haematologic malignancies. However, infection of acute organ dysfunction and graft versus …

The importance of graft cell composition in outcome after allogeneic stem cell transplantation in patients with malignant disease

P Svenberg, T Wang, M Uhlin, E Watz… - Clinical …, 2019 - Wiley Online Library
Background Graft‐versus‐host disease (GVHD) and relapse remain majobstacles ftreatment
success in allogeneic hematopoietic stem cell transplantation (HSCT). In the present study …