Depression—an underrecognized target for prevention of dementia in Alzheimer's disease

FS Dafsari, F Jessen - Translational psychiatry, 2020 - nature.com
It is broadly acknowledged that the onset of dementia in Alzheimer's disease (AD) may be
modifiable by the management of risk factors. While several recent guidelines and …

Comparative efficacy of interventions for reducing symptoms of depression in people with dementia: systematic review and network meta-analysis

JA Watt, Z Goodarzi, AA Veroniki, V Nincic, PA Khan… - bmj, 2021 - bmj.com
Objective To describe the comparative efficacy of drug and non-drug interventions for
reducing symptoms of depression in people with dementia who experience depression as a …

Antidepressants for treating depression in dementia

R Dudas, R Malouf, J McCleery… - Cochrane Database of …, 2018 - cochranelibrary.com
Background The use of antidepressants in dementia accompanied by depressive symptoms
is widespread, but their clinical efficacy is uncertain. This review updates an earlier version …

Impact of SSRI therapy on risk of conversion from mild cognitive impairment to Alzheimer's dementia in individuals with previous depression

C Bartels, M Wagner, S Wolfsgruber… - American Journal of …, 2018 - Am Psychiatric Assoc
Objective: Depression is associated with an increased risk of Alzheimer's disease. Research
has shown that the selective serotonin reuptake inhibitor (SSRI) citalopram decreases …

Depression in Alzheimer's disease: epidemiology, mechanisms, and treatment

YY Huang, YH Gan, L Yang, W Cheng, JT Yu - Biological Psychiatry, 2024 - Elsevier
Depression and Alzheimer's disease (AD) are substantial public health concerns. In the past
decades, a link between the 2 disease entities has received extensive acknowledgment, yet …

Alzheimer's disease large-scale gene expression portrait identifies exercise as the top theoretical treatment

MA Hill, SC Gammie - Scientific reports, 2022 - nature.com
Alzheimer's disease (AD) is a complex neurodegenerative disorder that affects multiple
brain regions and is difficult to treat. In this study we used 22 AD large-scale gene …

Causes, consequences, and cures for neuroinflammation mediated via the locus coeruleus: noradrenergic signaling system

DL Feinstein, S Kalinin, D Braun - Journal of neurochemistry, 2016 - Wiley Online Library
Aside from its roles in as a classical neurotransmitter involved in regulation of behavior,
noradrenaline (NA) has other functions in the CNS. This includes restricting the …

Principles and management of neuropsychiatric symptoms in Alzheimer's dementia

MA Nowrangi, CG Lyketsos, PB Rosenberg - Alzheimer's research & …, 2015 - Springer
Neuropsychiatric symptoms of Alzheimer's disease (NPS-AD) are highly prevalent and lead
to poor medical and functional outcomes. In spite of the burdensome nature of NPS-AD, we …

Depression, depression treatments, and risk of incident dementia: a prospective cohort study of 354,313 participants

L Yang, YT Deng, Y Leng, YN Ou, YZ Li, SD Chen… - Biological …, 2023 - Elsevier
Background The purpose of this study was to investigate the associations between courses
of depression, the application of depression treatment, and the risk of incident dementia …

Depression in Alzheimer's disease: a Delphi consensus on etiology, risk factors, and clinical management

L Agüera-Ortiz, R García-Ramos… - Frontiers in …, 2021 - frontiersin.org
Background: Alzheimer's disease (AD) and other forms of dementia are among the most
common causes of disability in the elderly. Dementia is often accompanied by depression …