Adropin's role in energy homeostasis and metabolic disorders

II Ali, C D'Souza, J Singh, E Adeghate - International journal of molecular …, 2022 - mdpi.com
Adropin is a novel 76-amino acid-peptide that is expressed in different tissues and cells
including the liver, pancreas, heart and vascular tissues, kidney, milk, serum, plasma and …

Adropin as a fat-burning hormone with multiple functions—Review of a decade of research

M Jasaszwili, M Billert, MZ Strowski, KW Nowak… - Molecules, 2020 - mdpi.com
Adropin is a unique hormone encoded by the energy homeostasis-associated (Enho) gene.
Adropin is produced in the liver and brain, and also in peripheral tissues such as in the heart …

Discovery of human signaling systems: pairing peptides to G protein-coupled receptors

SR Foster, AS Hauser, L Vedel, RT Strachan… - Cell, 2019 - cell.com
The peptidergic system is the most abundant network of ligand-receptor-mediated signaling
in humans. However, the physiological roles remain elusive for numerous peptides and …

Adropin contributes to anti-atherosclerosis by suppressing monocyte-endothelial cell adhesion and smooth muscle cell proliferation

K Sato, T Yamashita, R Shirai, K Shibata… - International journal of …, 2018 - mdpi.com
Adropin, a peptide hormone expressed in liver and brain, is known to improve insulin
resistance and endothelial dysfunction. Serum levels of adropin are negatively associated …

Adropin as a potential mediator of the metabolic system‐autonomic nervous system‐chronobiology axis: Implementing a personalized signature‐based platform for …

Y Kolben, S Weksler‐Zangen, Y Ilan - Obesity Reviews, 2021 - Wiley Online Library
Adropin is a peptide hormone, which plays a role in energy homeostasis and controls
glucose and fatty acid metabolism. Its levels correlate with changes in carbohydrate‐lipid …

[HTML][HTML] G protein-coupled receptor GPR19 regulates E-cadherin expression and invasion of breast cancer cells

A Rao, DR Herr - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2017 - Elsevier
Dysregulation of G protein-coupled receptors (GPCRs) is known to be involved in the
pathogenesis of a variety of diseases, including cancer initiation and progression. Within this …

[HTML][HTML] Adropin regulates pyruvate dehydrogenase in cardiac cells via a novel GPCR-MAPK-PDK4 signaling pathway

D Thapa, MW Stoner, M Zhang, B Xie, JR Manning… - Redox biology, 2018 - Elsevier
Mitochondria supply~ 90% of the ATP required for contractile function in cardiac cells. While
adult cardiomyocytes preferentially utilize fatty acids as a fuel source for oxidative …

Attenuation of fibroblast activation and fibrosis by adropin in systemic sclerosis

M Liang, N Dickel, AH Györfi… - Science Translational …, 2024 - science.org
Fibrotic diseases impose a major socioeconomic challenge on modern societies and have
limited treatment options. Adropin, a peptide hormone encoded by the energy homeostasis …

Adropin: a hepatokine modulator of vascular function and cardiac fuel metabolism

BAS Mushala, I Scott - American Journal of Physiology …, 2021 - journals.physiology.org
Adropin is a nutritionally regulated peptide hormone, secreted primarily by the liver, which
modulates metabolic homeostasis in a number of tissues. Growing evidence suggests that …

[HTML][HTML] Neurovascular protection by adropin in experimental ischemic stroke through an endothelial nitric oxide synthase-dependent mechanism

C Yang, BP Lavayen, L Liu, BD Sanz, KM DeMars… - Redox Biology, 2021 - Elsevier
Adropin is a highly-conserved peptide that has been shown to preserve endothelial barrier
function. Blood-brain barrier (BBB) disruption is a key pathological event in cerebral …