Prokaryotic heme biosynthesis: multiple pathways to a common essential product
The advent of heme during evolution allowed organisms possessing this compound to
safely and efficiently carry out a variety of chemical reactions that otherwise were difficult or …
safely and efficiently carry out a variety of chemical reactions that otherwise were difficult or …
Heme synthesis and acquisition in bacterial pathogens
Bacterial pathogens require the iron-containing cofactor heme to cause disease. Heme is
essential to the function of hemoproteins, which are involved in energy generation by the …
essential to the function of hemoproteins, which are involved in energy generation by the …
Formation and cleavage of C–C bonds by enzymatic oxidation–reduction reactions
FP Guengerich, FK Yoshimoto - Chemical Reviews, 2018 - ACS Publications
Many oxidation–reduction (redox) enzymes, particularly oxygenases, have roles in reactions
that make and break C–C bonds. The list includes cytochrome P450 and other heme-based …
that make and break C–C bonds. The list includes cytochrome P450 and other heme-based …
[HTML][HTML] Heme biosynthesis in prokaryotes
G Layer - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2021 - Elsevier
The cyclic tetrapyrrole heme is used as a prosthetic group in a broad variety of different
proteins in almost all organisms. Often, it is essential for vital biochemical processes such as …
proteins in almost all organisms. Often, it is essential for vital biochemical processes such as …
[HTML][HTML] Understanding molecular enzymology of porphyrin-binding α+ β barrel proteins-One fold, multiple functions
S Hofbauer, V Pfanzagl, H Michlits, D Schmidt… - … et Biophysica Acta (BBA …, 2021 - Elsevier
There is a high functional diversity within the structural superfamily of porphyrin-binding
dimeric α+ β barrel proteins. In this review we aim to analyze structural constraints of chlorite …
dimeric α+ β barrel proteins. In this review we aim to analyze structural constraints of chlorite …
Structure-based mechanism for oxidative decarboxylation reactions mediated by amino acids and heme propionates in coproheme decarboxylase (HemQ)
Coproheme decarboxylase catalyzes two sequential oxidative decarboxylations with H2O2
as the oxidant, coproheme III as substrate and cofactor, and heme b as the product. Each …
as the oxidant, coproheme III as substrate and cofactor, and heme b as the product. Each …
Substrate specificity and complex stability of coproporphyrin ferrochelatase is governed by hydrogen‐bonding interactions of the four propionate groups
T Gabler, F Sebastiani, J Helm, A Dali… - The FEBS …, 2022 - Wiley Online Library
Coproporpyhrin III is the substrate of coproporphyrin ferrochelatases (CpfCs). These
enzymes catalyse the insertion of ferrous iron into the porphyrin ring. This is the penultimate …
enzymes catalyse the insertion of ferrous iron into the porphyrin ring. This is the penultimate …
Redox Cofactor Rotates during Its Stepwise Decarboxylation: Molecular Mechanism of Conversion of Coproheme to Heme b
Coproheme decarboxylase (ChdC) catalyzes the last step in the heme biosynthesis pathway
of monoderm bacteria with coproheme acting both as redox cofactor and substrate …
of monoderm bacteria with coproheme acting both as redox cofactor and substrate …
The Role of the Hydrogen Bond Network in Maintaining Heme Pocket Stability and Protein Function Specificity of C. diphtheriae Coproheme Decarboxylase
Monoderm bacteria accumulate heme b via the coproporphyrin-dependent biosynthesis
pathway. In the final step, in the presence of two molecules of H2O2, the propionate groups …
pathway. In the final step, in the presence of two molecules of H2O2, the propionate groups …
Reaction intermediate rotation during the decarboxylation of coproheme to heme b in C. diphtheriae
Monoderm bacteria utilize coproheme decarboxylases (ChdCs) to generate heme b by a
stepwise decarboxylation of two propionate groups of iron coproporphyrin III (coproheme) …
stepwise decarboxylation of two propionate groups of iron coproporphyrin III (coproheme) …