The evolutionarily conserved Forkhead box O (FOXO) family of transcription factors
regulates multiple transcriptional targets involved in various cellular processes, including …

Cardiovascular disease is the leading cause of mortality worldwide. Excessive oxidative
stress and inflammation play an important role in the development and progression of …

The forkhead transcription factor Foxo3a is able to inhibit cardiomyocyte hypertrophy.
However, its underlying molecular mechanism remains to be fully understood. Our present …

Background—Associations between left ventricular (LV) geometry and the insulin resistance
syndrome have been found, mostly in small studies of middle-aged hypertensives. The …

To investigate the association between hyperinsulinemia and cardiac hypertrophy, we
treated rats with insulin for 7 wk and assessed effects on myocardial growth, vascularization …

Background Cardiac hypertrophy is characterized by alterations in both cardiac
bioenergetics and insulin sensitivity. Insulin promotes glucose uptake by cardiomyocytes …

Background—The metabolic syndrome has been associated with cardiovascular disease,
but few studies have examined its relationship with subclinical measures such as …

Cardiac hypertrophy is an adaptive response that compensates for increased workload by
normalizing wall stress and preserving cardiac contractile function. In advanced stages …

Objective: We studied uncomplicated obesity as a model to evaluate the influence of insulin
sensitivity per se on left ventricular mass (LVM) and geometry. Research Methods and …

Evidence for the role of electrocardiography or echocardiography in determining left
ventricular hypertrophy for the risk of diabetes is still controversial. We aimed to explore …