D Lingwood, K Simons - science, 2010 - science.org
Cell membranes display a tremendous complexity of lipids and proteins designed to perform the functions cells require. To coordinate these functions, the membrane is able to laterally …
A Romanauska, A Köhler - Nature Cell Biology, 2023 - nature.com
The nuclear envelope (NE) is a spherical double membrane with elastic properties. How NE shape and elasticity are regulated by lipid chemistry is unknown. Here we discover lipid acyl …
JH Lorent, B Diaz-Rohrer, X Lin, K Spring… - Nature …, 2017 - nature.com
Eukaryotic plasma membranes are compartmentalized into functional lateral domains, including lipid-driven membrane rafts. Rafts are involved in most plasma membrane …
FM Goñi - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2014 - Elsevier
The fluid mosaic model of Singer and Nicolson (1972) is a commonly used representation of the cell membrane structure and dynamics. However a number of features, the result of four …
The rice blast fungus Magnaporthe oryzae uses a pressurized infection cell called an appressorium to drive a rigid penetration peg through the leaf cuticle. The vast internal …
Steroid hormones are made from cholesterol, primarily derived from lipoproteins that enter cells via receptor-mediated endocytosis. In endo-lysosomes, cholesterol is released from …
FA Heberle, RS Petruzielo, J Pan… - Journal of the …, 2013 - ACS Publications
The observation of lateral phase separation in lipid bilayers has received considerable attention, especially in connection to lipid raft phenomena in cells. It is widely accepted that …
X Cheng, JC Smith - Chemical reviews, 2019 - ACS Publications
To execute their many vital functions, cell membranes are highly organized. Here, we review how membrane structure shapes signal transduction across membranes. Recent …
The Singer-Nicholson model of membranes postulated a uniform lipid bilayer randomly studded with floating proteins. However, it became clear almost immediately that …