Systemic inflammation after stroke: implications for post‐stroke comorbidities

A Simats, A Liesz - EMBO molecular medicine, 2022 - embopress.org
Immunological mechanisms have come into the focus of current translational stroke
research, and the modulation of neuroinflammatory pathways has been identified as a …

Immune pathways in etiology, acute phase, and chronic sequelae of ischemic stroke

M Endres, MA Moro, CH Nolte, C Dames… - Circulation …, 2022 - Am Heart Assoc
Inflammation and immune mechanisms are crucially involved in the pathophysiology of the
development, acute damage cascades, and chronic course after ischemic stroke …

Infection as a stroke risk factor and determinant of outcome after stroke

MSV Elkind, AK Boehme, CJ Smith, A Meisel… - Stroke, 2020 - Am Heart Assoc
Understanding the relationship between infection and stroke has taken on new urgency in
the era of the coronavirus disease 2019 (COVID-19) pandemic. This association is not a …

Immunodepression, infections, and functional outcome in ischemic stroke

WF Westendorp, C Dames, PJ Nederkoorn, A Meisel - Stroke, 2022 - Am Heart Assoc
Stroke remains one of the main causes of mortality and morbidity worldwide. Immediately
after stroke, a neuroinflammatory process starts in the brain, triggering a systemic …

The immunology of acute stroke

A Chamorro, A Meisel, AM Planas, X Urra… - Nature reviews …, 2012 - nature.com
Recent clinical and experimental studies have highlighted a complex role for the immune
system in the pathophysiological changes that occur after acute stroke. Sensors of the innate …

Targeting the immune system for ischemic stroke

SR Zhang, TG Phan, CG Sobey - Trends in pharmacological sciences, 2021 - cell.com
Stroke is responsible for almost 6 million deaths and more than 10% of all mortalities each
year, and two-thirds of stroke survivors remain disabled. With treatments for ischemic stroke …

Stroke and the immune system: from pathophysiology to new therapeutic strategies

R Macrez, C Ali, O Toutirais, B Le Mauff… - The Lancet …, 2011 - thelancet.com
Stroke is the second most common cause of death worldwide and a major cause of acquired
disability in adults. Despite tremendous progress in understanding the pathophysiology of …

DAMP signaling is a key pathway inducing immune modulation after brain injury

A Liesz, A Dalpke, E Mracsko, S Roth… - Journal of …, 2015 - Soc Neuroscience
Acute brain lesions induce profound alterations of the peripheral immune response
comprising the opposing phenomena of early immune activation and subsequent …

New horizons for newborn brain protection: enhancing endogenous neuroprotection

KJ Hassell, M Ezzati, D Alonso-Alconada… - Archives of Disease in …, 2015 - fn.bmj.com
Intrapartum-related events are the third leading cause of childhood mortality worldwide and
result in one million neurodisabled survivors each year. Infants exposed to a perinatal insult …

Stroke-induced immunodepression and dysphagia independently predict stroke-associated pneumonia–The PREDICT study

S Hoffmann, H Harms, L Ulm… - Journal of Cerebral …, 2017 - journals.sagepub.com
Stroke-associated pneumonia is a frequent complication after stroke associated with poor
outcome. Dysphagia is a known risk factor for stroke-associated pneumonia but …