Melatonin ameliorates cadmium-induced affective and cognitive impairments and hippocampal oxidative stress in rat

M Lamtai, S Azirar, O Zghari, S Ouakki… - … Trace Element Research, 2021 - Springer
The present work aims to evaluate the effect of melatonin (Mel) on affective and cognitive
disorders induced by chronic exposure to Cadmium (Cd). Male and female Wistar rats …

Effect of chronic administration of nickel on affective and cognitive behavior in male and female rats: possible implication of oxidative stress pathway

M Lamtai, J Chaibat, S Ouakki, O Zghari, A Mesfioui… - Brain sciences, 2018 - mdpi.com
Nickel (Ni) toxicity has been reported to produce biochemical and behavioral dysfunction.
The present study was undertaken to examine whether Ni chronic administration can induce …

[HTML][HTML] Neuropathological changes in brain cortex and hippocampus in a rat model of Alzheimer's disease

M Nobakht, SM Hoseini, P Mortazavi… - Iranian biomedical …, 2011 - ncbi.nlm.nih.gov
Background: Alzheimer's disease (AD) is a neurodegenerative disorder with progressive
loss of cognitive abilities and memory loss. The aim of this study was to compare …

Melatonin modulates copper-induced anxiety-like, depression-like and memory impairments by acting on hippocampal oxidative stress in rat

M Lamtai, O Zghari, S Azirar, S Ouakki… - Drug and Chemical …, 2022 - Taylor & Francis
Copper (Cu) is a heavy metal with the ability to induce, at high levels, neurobehavioral
alterations, and oxidative stress (OS). On the other hand, melatonin (Mel) is a neurohormone …

Exploring the neuroprotective role of melatonin against nickel-induced neurotoxicity in the left hippocampus

MY El Brouzi, M Lamtai, N Fath, A Rezqaoui, O Zghari… - Biometals, 2024 - Springer
Previous studies have demonstrated that the hippocampus, a crucial region for memory and
cognitive functions, is particularly vulnerable to adverse effects of exposure to heavy metals …

Chronic copper exposure leads to hippocampus oxidative stress and impaired learning and memory in male and female rats

M Lamtai, O Zghari, S Ouakki, I Marmouzi… - Toxicological …, 2020 - Springer
Environmental and occupational exposures to copper (Cu) play a pivotal role in the etiology
of some neurological diseases and reduced cognitive functions. However, the precise …

[HTML][HTML] Effect of chronic administration of cadmium on anxiety-like, depression-like and memory deficits in male and female rats: possible involvement of oxidative …

M Lamtai, J Chaibat, S Ouakki, I Berkiks, EH Rifi… - Journal of Behavioral …, 2018 - scirp.org
The main objective of this work is to study the effect of chronic administration of cadmium
(Cd) on the level of depression-like, anxiety-like, memory state and oxidative stress in male …

[HTML][HTML] Neuroprotective effect of melatonin on nickel-induced affective and cognitive disorders and oxidative damage in rats

M Lamtai, S Ouakki, O Zghari… - … Analysis, Health and …, 2020 - ncbi.nlm.nih.gov
The present work is carried out to explore the neuroprotective potential of Melatonin (Mel),
on Ni-induced neurobehavioral, biochemical and histological alterations in male and female …

Short term cadmium administration dose dependently elicits immediate biochemical, neurochemical and neurobehavioral dysfunction in male rats

S Haider, L Anis, Z Batool, I Sajid, F Naqvi… - Metabolic brain …, 2015 - Springer
Cadmium is a toxic environmental and industrial pollutant. Cadmium toxicity has been
reported to produce biochemical and behavioral dysfunction that may cause adverse effects …

Potentiation of the apoptotic signaling pathway in both the striatum and hippocampus and neurobehavioral impairment in rats exposed chronically to a low− dose of …

Z Chouit, D Djellal, S Haddad, M Hanfer… - … Science and Pollution …, 2021 - Springer
Cadmium (Cd) is a highly toxic heavy metal. It accumulates in biological tissues, especially
in fish which constitutes a first rank food for humans, particularly in the coastal areas. This …