Metabolic glycoengineering–exploring glycosylation with bioorthogonal chemistry

M Kufleitner, LM Haiber, V Wittmann - Chemical Society Reviews, 2023 - pubs.rsc.org
Glycans are involved in numerous biological recognition events. Being secondary gene
products, their labeling by genetic methods–comparable to GFP labeling of proteins–is not …

Metal-free bioorthogonal click chemistry in cancer theranostics

D Wu, K Yang, Z Zhang, Y Feng, L Rao… - Chemical Society …, 2022 - pubs.rsc.org
Bioorthogonal chemistry is a powerful tool to site-specifically activate drugs in living systems.
Bioorthogonal reactions between a pair of biologically reactive groups can rapidly and …

Chemically engineering cells for precision medicine

Y Wang, Z Li, F Mo, TJ Chen-Mayfield, A Saini… - Chemical Society …, 2023 - pubs.rsc.org
Cell-based therapy holds great potential to address unmet medical needs and revolutionize
the healthcare industry, as demonstrated by several therapeutics such as CAR-T cell …

Copper‐free click chemistry: applications in drug delivery, cell Tracking, and tissue engineering

HY Yoon, D Lee, DK Lim, H Koo, K Kim - Advanced Materials, 2022 - Wiley Online Library
Traditionally, organic chemical reactions require organic solvents, toxic catalysts, heat, or
high pressure. However, copper‐free click chemistry has been shown to have favorable …

Nanomaterials for diagnosis and treatment of brain cancer: Recent updates

M Mukhtar, M Bilal, A Rahdar, M Barani, R Arshad… - Chemosensors, 2020 - mdpi.com
Brain tumors, especially glioblastoma, remain the most aggressive form of all the cancers
because of inefficient diagnosis and profiling. Nanostructures, such as metallic …

Deep penetration of nanolevel drugs and micrometer-level T cells promoted by nanomotors for cancer immunochemotherapy

H Chen, T Shi, Y Wang, Z Liu, F Liu… - Journal of the …, 2021 - ACS Publications
The ability of nanomotors to promote the deep penetration of themselves and the loaded
drugs in diseased tissues has been proposed and confirmed. However, whether such …

Iron oxide nanoparticles in regenerative medicine and tissue engineering

RP Friedrich, I Cicha, C Alexiou - Nanomaterials, 2021 - mdpi.com
In recent years, many promising nanotechnological approaches to biomedical research
have been developed in order to increase implementation of regenerative medicine and …

Tumor‐targeting glycol chitosan nanoparticles for cancer heterogeneity

JH Ryu, HY Yoon, IC Sun, IC Kwon… - Advanced Materials, 2020 - Wiley Online Library
Nanomedicine is extensively employed for cancer treatment owing to its unique advantages
over conventional drugs and imaging agents. This increased attention to nanomedicine …

In vivo applications of bioorthogonal reactions: chemistry and targeting mechanisms

MMA Mitry, F Greco, HMI Osborn - Chemistry–A European …, 2023 - Wiley Online Library
Bioorthogonal chemistry involves selective biocompatible reactions between functional
groups that are not normally present in biology. It has been used to probe biomolecules in …

Temperature‐feedback nanoplatform for NIR‐II penta‐modal imaging‐guided synergistic photothermal therapy and CAR‐NK immunotherapy of lung cancer

M Xu, B Xue, Y Wang, D Wang, D Gao, S Yang, Q Zhao… - Small, 2021 - Wiley Online Library
In this study, to visually acquire all‐round structural and functional information of lung cancer
while performing synergistic photothermal therapy (PTT) and tumor‐targeting …