One could certainly highlight a conceptual resemblance between social interactions as the
basis of societies and civilizations and the ability of molecules to interact in a noncovalent …

Since the first description in 1989 of CD4‐Fc‐fusion antagonists that inhibit human immune
deficiency virus entry into T cells, Fc‐fusion proteins have been intensely investigated for …

Glycans are key participants in biological processes ranging from reproduction to cellular
communication to infection. Revealing glycan roles and the underlying molecular …

The study of biological processes has driven the efforts of modern molecular biology to
unravel the microscopic capabilities of natural systems. Intrinsic to the experimental analysis …

Glycans are ubiquitous components of all organisms. Efforts to elucidate glycan function and
to understand how they are assembled and disassembled can reap benefits in fields …

Conspectus Multivalent interactions are common in biological systems and are also widely
deployed for targeting applications in biomedicine. A unique feature of multivalent binding is …

Siglecs (sialic acid immunoglobulin-like lectins) are members of the immunoglobulin gene
family that contain sialoside binding N-terminal domains. They are cell surface proteins …

Prostate specific membrane antigen (PSMA) is a membrane-bound glutamate
carboxypeptidase overexpressed in many forms of prostate cancer. Our laboratory has …

The sialic-acid-binding immunoglobulin-like lectins (siglecs) comprise a family of receptors
that are differentially expressed on leukocytes and other immune cells. The restricted …

Antibody-mediated cell depletion therapy has proven to provide significant clinical benefit in
treatment of lymphomas and leukemias, driving the development of improved therapies with …