Adult zebrafish generate new neurons in the brain and retina throughout life. Growth-related
neurogenesis allows a vigorous regenerative response to damage, and fish can regenerate …

Over the past two decades, evidence has accumulated that neurogenesis can occur in both
the juvenile and adult mammalian hypothalamus. Levels of hypothalamic neurogenesis can …

Precise temporal control of gene expression in neuronal progenitors is necessary for correct
regulation of neurogenesis and cell fate specification. However, the cellular heterogeneity of …

To study the development of the human retina, we use single-cell RNA sequencing (RNA-
seq) at key fetal stages and follow the development of the major cell types as well as …

Müller glial cells are the source of retinal regeneration in fish and birds; although this
process is efficient in fish, it is less so in birds and very limited in mammals. It has been …

Non-mammalian vertebrates have a robust ability to regenerate injured retinal neurons from
Müller glia (MG) that activate the gene encoding the proneural factor Achaete-scute …

Most regions of the vertebrate central nervous system develop by the sequential addition of
different classes of neurons and glia. This phenomenon has been best characterized in …

The derivation of three-dimensional (3D) stratified neural retina from pluripotent stem cells
has permitted investigations of human photoreceptors. We have generated a H9 human …

Retinal dystrophies are a major cause of blindness for which there are currently no curative
treatments. Transplantation of stem cell‐derived neuronal progenitors to replace lost cells …

Müller glia originate from neuroepithelium and are the principal glial cells in the retina.
During retinal development, Müller glia are one of the last cell types to be born. In lower …