Effect of physicochemical and surface properties on in vivo fate of drug nanocarriers

Z Zhao, A Ukidve, V Krishnan, S Mitragotri - Advanced drug delivery …, 2019 - Elsevier
Over the years, a plethora of materials–natural and synthetic–have been engineered at a
nanoscopic level and explored for drug delivery. Nanocarriers based on such materials …

Designing smart polymer conjugates for controlled release of payloads

F Seidi, R Jenjob, D Crespy - Chemical reviews, 2018 - ACS Publications
Incorporating labile bonds inside polymer backbone and side chains yields interesting
polymer materials that are responsive to change of environmental stimuli. Drugs can be …

Nanomaterials: applications in cancer imaging and therapy

JA Barreto, W O'Malley, M Kubeil, B Graham… - Advanced …, 2011 - Wiley Online Library
The application of nanomaterials (NMs) in biomedicine is increasing rapidly and offers
excellent prospects for the development of new non‐invasive strategies for the diagnosis …

Cyclometalated iridium (III) complexes for life science

C Caporale, M Massi - Coordination Chemistry Reviews, 2018 - Elsevier
Photoluminescent cyclometalated iridium (III) complexes are now a well established class of
organometallic compounds with advantageous potential applications in biology and life …

Effects of nanomaterial physicochemical properties on in vivo toxicity

KL Aillon, Y Xie, N El-Gendy, CJ Berkland… - Advanced drug delivery …, 2009 - Elsevier
It is well recognized that physical and chemical properties of materials can alter dramatically
at nanoscopic scale, and the growing use of nanotechnologies requires careful assessment …

Soluble polymer carriers for the treatment of cancer: the importance of molecular architecture

ME Fox, FC Szoka, JMJ Fréchet - Accounts of chemical research, 2009 - ACS Publications
Chemotherapy can destroy tumors and arrest cancer progress. Unfortunately, severe side
effects (treatment is usually a series of injections of highly toxic drugs) often restrict the …

Design of biocompatible dendrimers for cancer diagnosis and therapy: current status and future perspectives

Y Cheng, L Zhao, Y Li, T Xu - Chemical Society Reviews, 2011 - pubs.rsc.org
In the past decade, nanomedicine with its promise of improved therapy and diagnostics has
revolutionized conventional health care and medical technology. Dendrimers and dendrimer …

Dendrimers as carriers for delivery of chemotherapeutic agents

SH Medina, MEH El-Sayed - Chemical reviews, 2009 - ACS Publications
Dendrimers are a family of nanosized, three-dimensional polymers characterized by a
unique tree-like branching architecture and compact spherical geometry in solution (Figure …

Advances in drug delivery and medical imaging using colloidal lyotropic liquid crystalline dispersions

X Mulet, BJ Boyd, CJ Drummond - Journal of colloid and interface science, 2013 - Elsevier
The overarching goal of this feature article is to review the recent developments in the field
of drug delivery specifically involving colloidal lyotropic liquid crystalline dispersions. The …

Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy

CM Patterson, SB Balachander, I Grant… - Communications …, 2021 - nature.com
Abstract Dual Bcl-2/Bcl-xL inhibitors are expected to deliver therapeutic benefit in many
haematological and solid malignancies, however, their use is limited by tolerability issues …