The fitness of an individual bacterial cell is highly dependent upon the temporal tuning of
gene expression levels when subjected to different environmental cues. Kinetic regulation of …

Pausing of transcribing RNA polymerase is regulated and creates opportunities to control
gene expression. Research in metazoans has so far mainly focused on RNA polymerase II …

RNA polymerases (RNAPs) carry out the first step in the central dogma of molecular biology
by transcribing DNA into RNA. Despite their importance, much about how RNAPs work …

Transcriptional pausing underpins the regulation of cellular RNA synthesis, but its
mechanism remains incompletely understood. Sequence-specific interactions of DNA and …

Summary RNA polymerase II (RNA Pol II) can backtrack during transcription elongation,
exposing the 3′ end of nascent RNA. Nascent RNA sequencing can approximate the …

Transcription initiation is highly regulated by promoter sequence, transcription factors, and
ligands. All known transcription inhibitors, an important class of antibiotics, act in initiation …

Acute kidney injury (AKI) has a high mortality rate, but its pathogenesis remains unclear
Lipopolysaccharide (LPS)-mediated renal tubular epithelial pyroptosis is involved in the …

In σ-dependent transcriptional pausing, the transcription initiation factor σ, translocating with
RNA polymerase (RNAP), makes sequence-specific protein–DNA interactions with a …

Transcription initiation starts with unwinding of promoter DNA by RNA polymerase (RNAP)
to form a catalytically competent RNAP-promoter complex (RPo). Despite extensive study …

Reiterative transcription initiation, observed at promoters that contain homopolymeric
sequences at the transcription start site, generates RNA products having 5′ sequences …