The Saccharomyces cerevisiae Set1/COMPASS was the first histone H3 lysine 4 (H3K4)
methylase identified over 10 years ago. Since then, it has been demonstrated that …

The transforming growth factor-β (TGF-β) system signals via protein kinase receptors and
SMAD mediators to regulate a large number of biological processes. Alterations of the TGF …

Colorectal cancer (CRC) is one of the most common cancer worldwide and results from the
accumulation of mutations and epimutations in colonic mucosa cells ultimately leading to …

Monomethylation of histone H3 on Lys 4 (H3K4me1) and acetylation of histone H3 on Lys
27 (H3K27ac) are histone modifications that are highly enriched over the body of actively …

Colorectal cancer (CRC) arise from multi-step carcinogenesis due to genetic mutations and
epigenetic modifications of human genome. Genetic mutations and epigenetic modifications …

African Americans have the highest incidence and mortality rates of colorectal cancer (CRC)
of any ethnic group in the United States. Although some of these disparities can be …

During development, precise spatiotemporal patterns of gene expression are coordinately
controlled by cis-regulatory modules known as enhancers. Their crucial role in development …

Why certain point mutations in a general transcription factor are associated with specific
forms of cancer has been a major question in cancer biology. Enhancers are DNA regulatory …

Methylation of histone H3 lysine 4 (H3K4) in Saccharomyces cerevisiae is implemented by
Set1/COMPASS, which was originally purified based on the similarity of yeast Set1 to human …

The mixed-lineage leukemia family of histone methyltransferases (MLL1–4, or KMT2A–D)
were previously linked to cancer through the founding member, MLL1/KMT2A, which is often …