Drug resistance represents a major obstacle in cancer management, and the mechanisms
underlying stress adaptation of cancer cells in response to therapy-induced hostile …

Metastatic dissemination of solid tumors, a leading cause of cancer-related mortality,
underscores the urgent need for enhanced insights into the molecular and cellular …

The ability of 2-deoxy-d-glucose (2-DG) to interfere with d-glucose metabolism demonstrates
that nutrient and energy deprivation is an efficient tool to suppress cancer cell growth and …

Most solid tumor cells adapt to their heterogeneous microenvironment by depending largely
on aerobic glycolysis for energy production, a phenomenon called the Warburg effect, which …

Cancer cells are frequently confronted with metabolic stress in tumor microenvironments
due to their rapid growth and limited nutrient supply. Metabolic stress induces cell death …

Mitochondria are indispensable for energy metabolism, apoptosis regulation, and cell
signaling. Mitochondria in malignant cells differ structurally and functionally from those in …

Mitochondria are the cells' powerhouse, but also their suicidal weapon store. Dozens of
lethal signal transduction pathways converge on mitochondria to cause the permeabilization …

The gastrointestinal microbiome plays a pivotal role in physiological homeostasis of the
intestine as well as in the pathophysiology of diseases including inflammatory bowel …

Simple Summary Reprogramming of glucose metabolism is a hallmark of cancer and can be
targeted by therapeutic agents. Some metabolism regulators, such as ivosidenib and …

The essential hallmarks of cancer are intertwined with an altered cancer cell-intrinsic
metabolism, either as a consequence or as a cause. As an example, the resistance of …