Sarcopenia: aging-related loss of muscle mass and function

L Larsson, H Degens, M Li, L Salviati… - Physiological …, 2018 - journals.physiology.org
Sarcopenia is a loss of muscle mass and function in the elderly that reduces mobility,
diminishes quality of life, and can lead to fall-related injuries, which require costly …

Inflammation and skeletal muscle wasting during cachexia

JM Webster, LJAP Kempen, RS Hardy… - Frontiers in …, 2020 - frontiersin.org
Cachexia is the involuntary loss of muscle and adipose tissue that strongly affects mortality
and treatment efficacy in patients with cancer or chronic inflammatory disease. Currently, no …

Cancer cachexia: molecular mechanisms and treatment strategies

T Setiawan, IN Sari, YT Wijaya, NM Julianto… - Journal of Hematology & …, 2023 - Springer
Muscle wasting is a consequence of physiological changes or a pathology characterized by
increased catabolic activity that leads to progressive loss of skeletal muscle mass and …

Metabolic syndrome and sarcopenia

H Nishikawa, A Asai, S Fukunishi, S Nishiguchi… - Nutrients, 2021 - mdpi.com
Skeletal muscle is a major organ of insulin-induced glucose metabolism. In addition, loss of
muscle mass is closely linked to insulin resistance (IR) and metabolic syndrome (Met-S) …

Role of myokines in regulating skeletal muscle mass and function

JH Lee, HS Jun - Frontiers in physiology, 2019 - frontiersin.org
Loss of skeletal muscle mass and strength has recently become a hot research topic with the
extension of life span and an increasingly sedentary lifestyle in modern society …

Cancer cachexia and its pathophysiology: links with sarcopenia, anorexia and asthenia

S Peixoto da Silva, JMO Santos… - Journal of cachexia …, 2020 - Wiley Online Library
Cancer cachexia is a multifactorial syndrome characterized by a progressive loss of skeletal
muscle mass, along with adipose tissue wasting, systemic inflammation and other metabolic …

Sarcopenia, frailty and their prevention by exercise

CM Nascimento, M Ingles, A Salvador-Pascual… - Free Radical Biology …, 2019 - Elsevier
Sarcopenia is a major component of the frailty syndrome, both being considered as strong
predictors of morbidity, disability, and death in older people. In this review, we explore the …

Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength

AR Palla, M Ravichandran, YX Wang, L Alexandrova… - Science, 2021 - science.org
INTRODUCTION Currently there are no approved treatments for sarcopenia, the age-
dependent loss of skeletal muscle mass and strength that constitutes a major public health …

Mechanisms of vitamin D on skeletal muscle function: oxidative stress, energy metabolism and anabolic state

KP Dzik, JJ Kaczor - European journal of applied physiology, 2019 - Springer
Purpose This review provides a current perspective on the mechanism of vitamin D on
skeletal muscle function with the emphasis on oxidative stress, muscle anabolic state and …

Effects of exercise and aging on skeletal muscle

G Distefano, BH Goodpaster - Cold Spring …, 2018 - perspectivesinmedicine.cshlp.org
A substantial loss of muscle mass and strength (sarcopenia), a decreased regenerative
capacity, and a compromised physical performance are hallmarks of aging skeletal muscle …