Sevoflurane, a volatile anaesthetic agent well-tolerated for inhalation induction, provides a
useful opportunity to elucidate the processes whereby halogenated ethers disrupt …

General anesthetics are a class of drugs that target the central nervous system and are
widely used for various medical procedures. General anesthetics produce many behavioral …

Anaesthesia is often a necessary step when studying insects like the model organism
Drosophila melanogaster. Most studies of Drosophila and other insects that require …

Modern anesthetic compounds and advanced monitoring tools have revolutionized the field
of medicine, allowing for complex surgical procedures to occur safely and effectively. Faster …

General anesthesia is a relatively safe medical procedure, which for nearly 170 years has
allowed life saving surgical interventions in animals and people. However, the molecular …

Halogenated inhaled general anesthetic agents modulate voltage-gated ion channels, but
the underlying molecular mechanisms are not understood. Many general anesthetic agents …

The molecular targets and neural circuits that underlie general anesthesia are not fully
elucidated. Here, we directly demonstrate that Kv1-family (Shaker-related) delayed rectifier …

General anesthesia is an unconscious state induced by anesthetics for surgery. The
molecular targets and cellular mechanisms of general anesthetics in the mammalian …

Sevoflurane is a commonly used inhaled general anesthetic. Despite this, its mechanism of
action remains largely elusive. Compared to other anesthetics, sevoflurane exhibits distinct …

Most general anesthetics enhance GABA type A (GABA A) receptor activity at clinically
relevant concentrations. Sites of action of volatile anesthetics on the GABA A receptor …