Engineered exosomes from different sources for cancer-targeted therapy

M Zhang, S Hu, L Liu, P Dang, Y Liu, Z Sun… - Signal transduction and …, 2023 - nature.com
Exosome is a subgroup of extracellular vesicles, which has been serving as an efficient
therapeutic tool for various diseases. Engineered exosomes are the sort of exosomes …

Emerging prospects of exosomes for cancer treatment: from conventional therapy to immunotherapy

GH Nam, Y Choi, GB Kim, S Kim, SA Kim… - Advanced …, 2020 - Wiley Online Library
Exosomes are a class of extracellular vesicles of around 100 nm in diameter that are
secreted by most cells and contain various bioactive molecules reflecting their cellular origin …

Rapid, deep and precise profiling of the plasma proteome with multi-nanoparticle protein corona

JE Blume, WC Manning, G Troiano, D Hornburg… - Nature …, 2020 - nature.com
Large-scale, unbiased proteomics studies are constrained by the complexity of the plasma
proteome. Here we report a highly parallel protein quantitation platform integrating …

Nano-drug delivery systems entrapping natural bioactive compounds for cancer: recent progress and future challenges

VP Chavda, AB Patel, KJ Mistry, SF Suthar… - Frontiers in …, 2022 - frontiersin.org
Cancer is a prominent cause of mortality globally, and it becomes fatal and incurable if it is
delayed in diagnosis. Chemotherapy is a type of treatment that is used to eliminate …

Paclitaxel's mechanistic and clinical effects on breast cancer

TM Abu Samaan, M Samec, A Liskova, P Kubatka… - Biomolecules, 2019 - mdpi.com
Paclitaxel (PTX), the most widely used anticancer drug, is applied for the treatment of
various types of malignant diseases. Mechanisms of PTX action represent several ways in …

Recent advances of cocktail chemotherapy by combination drug delivery systems

Q Hu, W Sun, C Wang, Z Gu - Advanced drug delivery reviews, 2016 - Elsevier
Combination chemotherapy is widely exploited for enhanced cancer treatment in the clinic.
However, the traditional cocktail administration of combination regimens often suffers from …

Anticancer drugs: recent strategies to improve stability profile, pharmacokinetic and pharmacodynamic properties

G Ioele, M Chieffallo, MA Occhiuzzi, M De Luca… - Molecules, 2022 - mdpi.com
In past decades, anticancer research has led to remarkable results despite many of the
approved drugs still being characterized by high systemic toxicity mainly due to the lack of …

Paclitaxel: What has been done and the challenges remain ahead

E Bernabeu, M Cagel, E Lagomarsino… - International journal of …, 2017 - Elsevier
In recent years, the nanotechnology has offered researchers the opportunity to solve the
problems caused by the vehicle of the standard and first formulation of paclitaxel (Taxol®) …

Microtubule targeting agents in disease: classic drugs, novel roles

L Wordeman, JJ Vicente - Cancers, 2021 - mdpi.com
Simple Summary Microtubules (MTs) are highly conserved proteins present in all eukaryotic
organisms. They form the cell cytoskeleton, and its function is essential for a large number of …

Nanoparticle-based drug delivery system: a patient-friendly chemotherapy for oncology

L Yan, J Shen, J Wang, X Yang, S Dong… - Dose …, 2020 - journals.sagepub.com
Chemotherapy is widely used to treat cancer. The toxic effect of conventional
chemotherapeutic drugs on healthy cells leads to serious toxic and side effects of …