Aminoacyl-tRNA synthetases (ARSs) are universal enzymes that catalyze the attachment of
amino acids to the 3′ ends of their cognate tRNAs. The resulting aminoacylated tRNAs are …

Aminoacyl-tRNA synthetases (aaRSs) catalyze the esterification of tRNA with a cognate
amino acid and are essential enzymes in all three kingdoms of life. Due to their important …

The trend toward designing large hydrophobic molecules for lead optimization is often
associated with poor drug-likeness and high attrition rates in drug discovery and …

Aminoacyl-tRNA synthetases (ARSs) are essential enzymes that ligate amino acids to
tRNAs and translate the genetic code during protein synthesis. Their function in pathogen …

Aminoacyl-tRNA synthetases (aaRSs) widely exist in organisms and mediate protein
synthesis. Inhibiting these synthetases can lead to the termination of protein synthesis and …

Threonyl-tRNA synthetase (ThrRS) is a key member of the aminoacyl-tRNA synthetase
(aaRS) family that plays essential roles in protein biosynthesis, and ThrRS inhibitors have …

Leucyl-tRNA synthetase (LeuRS) is a clinically validated target for the development of
antimicrobials. This enzyme catalyzes the formation of charged tRNA Leu molecules, an …

Mycothiol (MSH), the major cellular thiol in Mycobacterium tuberculosis (Mtb), plays an
essential role in the resistance of Mtb to various antibiotics and oxidative stresses. MshC …

Exchange proteins directly activated by cAMP (EPAC) play a central role in various
biological functions, and activation of the EPAC1 protein has shown potential benefits for the …

Benzene sulfonamides are an important biological substituent for several activities. In this
study, hybridization of benzene sulfonamide with piperazine derivatives were investigated …