Research priorities for an HIV cure: international AIDS society global scientific strategy 2021

SG Deeks, N Archin, P Cannon, S Collins, RB Jones… - Nature medicine, 2021 - nature.com
Despite the success of antiretroviral therapy (ART) for people living with HIV, lifelong
treatment is required and there is no cure. HIV can integrate in the host genome and persist …

Recommendations for measuring HIV reservoir size in cure-directed clinical trials

M Abdel-Mohsen, D Richman, RF Siliciano… - Nature medicine, 2020 - nature.com
Therapeutic strategies are being clinically tested either to eradicate latent HIV reservoirs or
to achieve virologic control in the absence of antiretroviral therapy. Attaining this goal will …

Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial

PM Folegatti, KJ Ewer, PK Aley, B Angus, S Becker… - The Lancet, 2020 - thelancet.com
Background The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) might be curtailed by vaccination. We assessed the safety, reactogenicity, and …

[HTML][HTML] COVID-19: the gendered impacts of the outbreak

C Wenham, J Smith, R Morgan - The lancet, 2020 - thelancet.com
The response to coronavirus disease 2019 (COVID-19) appears no different. We are not
aware of any gender analysis of the outbreak by global health institutions or governments in …

Early intervention with 3BNC117 and romidepsin at antiretroviral treatment initiation in people with HIV-1: a phase 1b/2a, randomized trial

JD Gunst, MH Pahus, M Rosás-Umbert, IN Lu… - Nature medicine, 2022 - nature.com
Attempts to reduce the human immunodeficiency virus type 1 (HIV-1) reservoir and induce
antiretroviral therapy (ART)-free virologic control have largely been unsuccessful. In this …

Safety, immunogenicity and effect on viral rebound of HTI vaccines in early treated HIV-1 infection: a randomized, placebo-controlled phase 1 trial

L Bailón, A Llano, S Cedeño, T Escribà… - Nature Medicine, 2022 - nature.com
Abstract HIVACAT T-cell immunogen (HTI) is a novel human immunodeficiency virus (HIV)
vaccine immunogen designed to elicit cellular immune responses to HIV targets associated …

Curing HIV: seeking to target and clear persistent infection

DM Margolis, NM Archin, MS Cohen, JJ Eron, G Ferrari… - Cell, 2020 - cell.com
Human immunodeficiency virus type 1 (HIV-1) infection persists despite years of
antiretroviral therapy (ART). To remove the stigma and burden of chronic infection …

Effect of 3BNC117 and romidepsin on the HIV-1 reservoir in people taking suppressive antiretroviral therapy (ROADMAP): a randomised, open-label, phase 2A trial

H Gruell, JD Gunst, YZ Cohen, MH Pahus… - The Lancet …, 2022 - thelancet.com
Background The administration of broadly neutralising anti-HIV-1 antibodies before latency
reversal could facilitate elimination of HIV-1-infected CD4 T cells. We tested this concept by …

HIVconsv vaccines and romidepsin in early-treated HIV-1-infected individuals: safety, immunogenicity and effect on the viral reservoir (Study BCN02)

B Mothe, M Rosás-Umbert, P Coll, C Manzardo… - Frontiers in …, 2020 - frontiersin.org
Kick&kill strategies combining drugs aiming to reactivate the viral reservoir with therapeutic
vaccines to induce effective cytotoxic immune responses hold potential to achieve a …

SARS CoV-2 mRNA vaccination exposes latent HIV to Nef-specific CD8+ T-cells

EM Stevenson, S Terry, D Copertino, L Leyre… - Nature …, 2022 - nature.com
Efforts to cure HIV have focused on reactivating latent proviruses to enable elimination by
CD8+ cytotoxic T-cells. Clinical studies of latency reversing agents (LRA) in antiretroviral …