The scientific landscape surrounding amyotrophic lateral sclerosis (ALS) continues to shift
as the number of genes associated with the disease risk and pathogenesis, and the cellular …

During cellular respiration, radicals, such as superoxide, are produced, and in a large
concentration, they may cause cell damage. To combat this threat, the cell employs the …

The increased application of transcriptome-wide profiling approaches has led to an
explosion in the number of documented long non-coding RNAs (lncRNAs). While these new …

The DNA and RNA processing protein TDP-43 undergoes both functional and pathogenic
aggregation. Functional TDP-43 aggregates form reversible, transient species such as …

Frontotemporal dementia (FTD) is a clinical syndrome with a heterogeneous molecular
basis. The past decade has seen the discovery of several new FTD‐causing genetic …

Parkinsonism, the clinical term for a disorder with prominent bradykinesia and variable
associated extrapyramidal signs and symptoms, is accompanied by degeneration of the …

Prions are self-templating protein conformers that are naturally transmitted between
individuals and promote phenotypic change. In yeast, prion-encoded phenotypes can be …

The normally soluble TAR DNA-binding protein 43 (TDP-43) is found aggregated both in
reversible stress granules and in irreversible pathogenic amyloid. In TDP-43, the low …

TDP-43 encodes an alternative-splicing regulator with tandem RNA-recognition motifs
(RRMs). The protein regulates cystic fibrosis transmembrane regulator (CFTR) exon 9 …

Frontotemporal dementia (FTD) is a clinical syndrome with a heterogeneous molecular
basis. Until recently, the underlying cause was known in only a minority of cases that were …