Macrophages represent the first line of anti-pathogen defense-they encounter invading
pathogens to perform the phagocytic activity, to deliver the plethora of pro-and anti …

Community-acquired pneumonia (CAP) is the leading cause of infectious death in the world.
Immune dysregulation during acute lung infection plays a role in lung injury and the …

Despite the rapid global increase of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection, there is currently no effective treatment for patients who have …

Abstract Background Elevated Interleukin-6 (IL-6) may play an important role in the
pathophysiology of COVID-19 yet attenuated response is not seen across all severe …

Abstract Background Coronavirus Disease 2019 (COVID-19) is a global pandemic, and
mortality and clinical consequences vary across countries. One of the factors influencing …

The role of host genetic variation in pneumonia development and outcome is poorly
understood. We studied common polymorphisms in the genes of proinflammatory cytokines …

The aim of this study was to explore the association between some SNPs of the TNF, LTA,
IL1B and IL10 genes with cytokine concentrations and clinical course in Colombian septic …

Background Knowledge of the risk factors for and causes of treatment failure and mortality in
childhood pneumonia is important for prevention, diagnosis, and treatment at an individual …

The association between interleukin (IL)-6 promoter polymorphism (-174 G/C), circulating IL-
6 levels and mortality in septic patients has scarcely been addressed, and then only in …

Objectives COVID-19 continues to range around the world and set morbidity and mortality
antirecords. Determining the role of genetic factors in the development of COVID-19 may …