Gonadal development is a complex process that involves sex determination followed by
divergent maturation into either testes or ovaries. Historically, limited tissue accessibility, a …

Single cell genomics encompasses a suite of rapidly maturing technologies that measure
the molecular profiles of individual cells within target samples. These approaches provide a …

Single-cell RNA sequencing (scRNA-seq) has revolutionized our understanding of cellular
heterogeneity and the dynamics of gene expression, bearing profound significance in stem …

Gonadal sex determination represents a unique model for studying cell fate decisions.
However, a complete understanding of the different cell lineages forming the developing …

Gametes are generated through a specialized cell differentiation process, meiosis, which, in
ovaries of most mammals, is initiated during fetal life. All-trans retinoic acid (ATRA) is …

During embryonic development, mutually antagonistic signaling cascades determine
gonadal fate toward a testicular or ovarian identity. Errors in this process result in disorders …

Meiosis is critical to generating oocytes and ensuring female fertility; however, the
mechanisms regulating the switch from mitotic primordial germ cells to meiotic germ cells …

Germ cells form the basis for sexual reproduction by producing gametes. In ovaries,
primordial germ cells exit the cell cycle and the pluripotency-associated state, differentiate …

Sex-specific gonadal differentiation is initiated by the expression of SRY in male foetuses.
This promotes a signalling pathway directing testicular development, while in female …

Avian germ cells can be distinguished by certain characteristics during development. On the
basis of these characteristics, germ cells can be used for germline transmission. However …