There is a myriad of enzymes within the body responsible for maintaining homeostasis by
providing the means to convert substrates to products as and when required. Physiological …

Our lab previously established that metformin, a first-line type two diabetes treatment,
activates the Nrf2 pathway and improves post-stroke recovery. Metformin's brain …

Metformin's potential in treating ischemic stroke and neurodegenerative conditions is of
growing interest. Yet, the absence of established systemic and brain pharmacokinetic (PK) …

As we often learn from nature, elucidation and understanding of the brain's endogenous self-
protective and recovery mechanisms have been an emerging approach in the stroke …

Purpose There is growing interest in seeking pharmacological activation of neurolysin (Nln)
for stroke treatment. Discovery of central nervous system drugs remains challenging due to …

Quetiapine hemifumarate (QF) delivery to the CNS via conventional formulations is
challenging due to poor solubility and lower oral bioavailability (9%). Similarly, many other …

Opioids represent the most extensive category of abused substances in the United States,
and the number of fatalities caused by these drugs exceeds those associated with all other …

The peptidase neurolysin (Nln) has been validated as a potential target for developing
therapeutics for ischemic stroke (IS). Overexpression of Nln in a mouse model of IS provides …

Milnacipran is a dual serotonin and norepinephrine reuptake inhibitor, clinically used for the
treatment of major depression or fibromyalgia. Currently, there are no studies reporting the …

Current targeted therapies for non-small cell lung cancer (NSCLC) face significant
limitations, primarily due to the small proportion of patients who respond to existing targets …