Histopathology in the placentae of women with antiphospholipid antibodies: a systematic review of the literature

CA Viall, LW Chamley - Autoimmunity reviews, 2015 - Elsevier
Background Antiphospholipid antibodies (aPLs) are a heterogenous group of
autoantibodies associated with recurrent miscarriage, stillbirth, foetal growth restriction and …

Aspirin: the mechanism of action revisited in the context of pregnancy complications

AP Cadavid - Frontiers in immunology, 2017 - frontiersin.org
Aspirin is one of the most frequently used and cheapest drugs in medicine. It belongs to the
non-steroidal anti-inflammatory drugs with a wide range of pharmacological activities …

Antiphospholipid antibodies and the placenta: a systematic review of their in vitro effects and modulation by treatment

M Tong, CA Viall, LW Chamley - Human reproduction update, 2015 - academic.oup.com
BACKGROUND Antiphospholipid antibodies (aPL) are a family of auto-antibodies that are
associated with an increased risk of recurrent miscarriage, intrauterine growth restriction and …

[HTML][HTML] Hydroxychloroquine restores trophoblast fusion affected by antiphospholipid antibodies

T Marchetti, A Ruffatti, C Wuillemin… - Journal of Thrombosis …, 2014 - Elsevier
Background Obstetric antiphospholipid syndrome (APS) is defined by pregnancy
complications associated with antiphospholipid antibodies (aPL). The mechanisms of the …

Obstetrical antiphospholipid syndrome: from the pathogenesis to the clinical and therapeutic implications

T Marchetti, M Cohen… - Journal of Immunology …, 2013 - Wiley Online Library
Antiphospholipid syndrome (APS) is an acquired thrombophilia with clinical manifestations
associated with the presence of antiphospholipid antibodies (aPL) in patient plasma …

Purified IgG from patients with obstetric but not IgG from non‐obstetric antiphospholipid syndrome inhibit trophoblast invasion

K Poulton, VM Ripoll, C Pericleous… - American Journal of …, 2015 - Wiley Online Library
Problem Some patients with antiphospholipid syndrome (APS) suffer pregnancy morbidity
(PM) but not vascular thrombosis (VT), whilst others suffer VT only. Therefore, we compared …

Complementemia in pregnancies with antiphospholipid syndrome

S Tabacco, A Giannini, C Garufi, A Botta, S Salvi… - Lupus, 2019 - journals.sagepub.com
Prognosis of pregnancies in women with antiphospholipid syndrome has dramatically
improved over the past two decades using conventional treatment with low molecular weight …

From antibody to clinical phenotype, the black box of the antiphospholipid syndrome: pathogenic mechanisms of the antiphospholipid syndrome

VX Du, H Kelchtermans, PG de Groot, B de Laat - Thrombosis Research, 2013 - Elsevier
The antiphospholipid syndrome (APS) is diagnosed by the combination of vascular
thrombosis and/or pregnancy morbidity and the detection of antiphospholipid antibodies …

Trophoblast cell function in the antiphospholipid syndrome

S Vrzić Petronijević, A Vilotić, Ž Bojić-Trbojević… - Biomedicines, 2023 - mdpi.com
Antiphospholipid syndrome (APS) is a complex thrombo-inflammatory autoimmune disease
characterized by the presence of antiphospholipid antibodies (aPL). Women with APS are at …

Human extravillous trophoblasts bind but do not internalize antiphospholipid antibodies

CA Viall, Q Chen, PR Stone, LW Chamley - Placenta, 2016 - Elsevier
Introduction Obstetric morbidity in women with antiphospholipid antibodies (aPLs) may
reflect the adverse effects of aPLs on placental cells such as extravillous trophoblasts and …