Alzheimer's disease (AD) is a neurodegenerative disorder that affects more than 37 million
people worldwide. Current drugs for AD are only symptomatic, but do not interfere with the …

Transforming growth factor β (TGFβ) family members are involved in a wide range of diverse
functions and play key roles in embryogenesis, development and tissue homeostasis …

Cyclooxygenase-1 [COX-1, prostaglandin synthase] catalyses the transformation of
arachidonic acid to the unstable intermediate prostaglandin PGH2. Subsequently …

Aims: Oxidative stress and inflammation are leading risk factors for age-associated
functional declines. We assessed aspirin effects on endogenous oxidative-stress levels …

Aspirin (ASA) has historically been one of the most important drugs in cardiology and has
long been the cornerstone of antiplatelet therapy. Although its role in acute coronary …

A soluble form of endoglin (sEng) is known to be an extracellular domain of the full-length
membrane endoglin, which is elevated during various pathological conditions related to …

Coxibs, such as rofecoxib, celecoxib, and valdecoxib, selectively inhibit cyclooxygenase
(COX)-2, the mainly inducible, pro-inflammatory COX isoform. Unlike traditional non …

Transforming growth factor‐β1 (TGF‐β1) is a polypeptide member of the transforming growth
factor β superfamily of cytokines. It is a secreted protein that performs many cellular functions …

Repaired Achilles tendons typically take weeks before they are strong enough to handle
physiological loads. Gene therapy is a promising treatment for Achilles tendon defects. The …

Activated platelets are involved in the atherogenic stage of atherosclerosis, while they can
also progress it to atherothrombosis which may cause an ischemic state and organ failure. In …